Wir arbeiten daran, alle Publikationen auf MACAU frei zugänglich zu machen.

Jaeger SU, Wohlrab M, Schoene D, Tremmel R, Chambers M, Leocani L, Corriol-Rohou S, Klenk J, Sharrack B, Garcia-Aymerich J, Rochester L, Maetzler W, Puhan M, Schwab M, Becker C (2022), Mobility endpoints in marketing authorisation of drugs: what gets the European medicines agency moving? Age and ageing 51(1), afab 242, doi: 10.1093/ageing/afab242.
Prell T, Uhlig M, Derlien S, Maetzler W, Zipprich HM (2022), Fear of Falling Does Not Influence Dual-Task Gait Costs in People with Parkinson's Disease: A Cross-Sectional Study. Sensors (Basel, Switzerland) 22(5), 2029, doi: 10.3390/s22052029.
Salem M, Hillmer J, Friedrich C, Panholzer B, Saad M, Salem M, Frank D, Ernst M, Maetzler W, Puehler T, Lutter G, Schoeneich F, Haneya A, Cremer J, Schoettler J (2022), Cardiac Myxomas Resembling Malignant Neoplasia: Incidentally Diagnosed vs. Cerebral Embolized Myxomas. Cancers 14(5), 1111, doi: 10.3390/cancers14051111.
Bhidayasiri R, Maytharakcheep S, Phumphid S, Maetzler W (2022), Improving functional disability in patients with tremor: A clinical perspective of the efficacies, considerations, and challenges of assistive technology. Journal of the Neurological Sciences 435, 120197, doi: 10.1016/j.jns.2022.120197.
Margraf NG, Jensen-Kondering U, Weiler C, Leypoldt F, Maetzler W, Philippen S, Bartsch T, Flüh C, Röcken C, Möller B, Royl G, Neumann A, Brüggemann N, Roeben B, Schulte C, Bender B, Berg D, Kuhlenbäumer G (2022), Cerebrospinal Fluid Biomarkers in Cerebral Amyloid Angiopathy: New Data and Quantitative Meta-Analysis. Frontiers in aging neuroscience 14, 783996, doi: 10.3389/fnagi.2022.783996.
Langer A, Lucke-Paulig L, Gassner L, Krüger R, Weiss D, Gharabaghi A, Zach H, Maetzler W, Hobert MA (2022), Additive Effect of Dopaminergic Medication on Gait Under Single and Dual-Tasking Is Greater Than of Deep Brain Stimulation in Advanced Parkinson Disease With Long-duration Deep Brain Stimulation. Neuromodulation: journal of the International Neuromodulation Society S1094-7159(22), 00036-8, doi: 10.1016/j.neurom.2022.01.015.
Gassner L, Dabnichki P, Pokan R, Schmoeger M, Willinger U, Maetzler W, Moser H, Zach H (2022), Therapeutic climbing in Parkinson's disease: Differences in self-reported health and well-being, feasibility and clinical changes. Physiotherapy theory and practice 1-15, doi: 10.1080/09593985.2022.2036279.
Corrà MF, Vila-Chã N, Sardoeira A, Hansen C, Sousa AP, Reis I, Sambayeta F, Damásio J, Calejo M, Schicketmueller A, Laranjinha I, Salgado P, Taipa R, Magalhães R, Correia M, Maetzler W, Maia LF (2022), Peripheral neuropathy in Parkinson's disease: prevalence and functional impact on gait and balance. Brain: a journal of neurology, doi: 10.1093/brain/awac026.
Gschmack E, Monoranu C-M, Marouf H, Meyer S, Lessel L, Idris R, Berg D, Maetzler W, Steigerwald F, Volkmann J, Gerlach M, Riederer P, Koutsilieri E, Scheller C (2022), Plasma autoantibodies to glial fibrillary acidic protein (GFAP) react with brain areas according to Braak staging of Parkinson's disease. Journal of neural transmission (Vienna, Austria : 1996), doi: 10.1007/s00702-022-02495-4.
Hansen C, Ortlieb C, Romijnders R, Warmerdam E, Welzel J, Geritz J, Maetzler W (2022), Reliability of IMU-Derived Temporal Gait Parameters in Neurological Diseases. Sensors 22(6), 2304, doi: 10.3390/s22062304.
Warmerdam E, Schumacher M, Beyer T, Nerdal PT, Schebesta L, Stürner KH, Zeuner KE, Hansen C, Maetzler W (2022), Postural Sway in Parkinson's Disease and Multiple Sclerosis Patients During Tasks With Different Complexity. Frontiers in neurology 13, 857406, doi: 10.3389/fneur.2022.857406.
Sulzer P, Gräber S, Schaeffer E, van Lummel R, Berg D, Maetzler W, Liepelt-Scarfone I (2021), Cognitive impairment and sedentary behavior predict health-related attrition in a prospective longitudinal Parkinson's disease study. Parkinsonism & related disorders 82, 37-43, doi: 10.1016/j.parkreldis.2020.11.015.
Maetzler W, Rochester L, Bhidayasiri R, Espay AJ, Sánchez-Ferro A, van Uem JMT (2021), Modernizing Daily Function Assessment in Parkinson's Disease Using Capacity, Perception, and Performance Measures. Movement disorders 36(1), 76-82, doi: 10.1002/mds.28377.
Becker S, Granert O, Timmers M, Pilotto A, Van Nueten L, Roeben B, Salvadore G, Galpern WR, Streffer J, Scheffler K, Maetzler W, Berg D, Liepelt-Scarfone I (2021), Association of Hippocampal Subfields, CSF Biomarkers, and Cognition in Patients With Parkinson Disease Without Dementia. Neurology 96(6), e904-e915, doi: 10.1212/WNL.0000000000011224.
Bayot M, Delval A, Moreau C, Defebvre L, Hansen C, Maetzler W, Schlenstedt C (2021), Initial center of pressure position prior to anticipatory postural adjustments during gait initiation in people with Parkinson's disease with freezing of gait. Parkinsonism & related disorders 84, 8-14, doi: 10.1016/j.parkreldis.2021.01.012.
Romijnders R, Warmerdam E, Hansen C, Welzel J, Schmidt G, Maetzler W (2021), Validation of IMU-based gait event detection during curved walking and turning in older adults and Parkinson's Disease patients. Journal of neuroengineering and rehabilitation 18(1), 28, doi: 10.1186/s12984-021-00828-0.
Becker S, Boettinger O, Sulzer P, Hobert MA, Brockmann K, Maetzler W, Berg D, Liepelt-Scarfone I, Gifford K (2021), Everyday Function in Alzheimer's and Parkinson's Patients with Mild Cognitive Impairment. Journal of Alzheimer's disease 79(1), 197-209, doi: 10.3233/JAD-200256.
Pilotto A, Zipser CM, Leks E, Haas D, Gramer G, Freisinger P, Schaeffer E, Liepelt-Scarfone I, Brockmann K, Maetzler W, Schulte C, Deuschle C, Hauser AK, Hoffmann GF, Scheffler K, van Spronsen FJ, Padovani A, Trefz F, Berg D (2021), Phenylalanine Effects on Brain Function in Adult Phenylketonuria. Neurology 96(3), e399-e411, doi: 10.1212/WNL.0000000000011088.
Atrsaei A, Corrà MF, Dadashi F, Vila-Chã N, Maia L, Mariani B, Maetzler W, Aminian K (2021), Gait speed in clinical and daily living assessments in Parkinson's disease patients: performance versus capacity. npj Parkinson's disease 7(1), 24, doi: 10.1038/s41531-021-00171-0.
Nissen SK, Ferreira SA, Nielsen MC, Schulte C, Shrivastava K, Hennig D, Etzerodt A, Graversen JH, Berg D, Maetzler W, Panhelainen A, Møller HJ, Brockmann K, Romero-Ramos M (2021), Soluble CD163 Changes Indicate Monocyte Association With Cognitive Deficits in Parkinson's Disease. Movement disorders 36(4), 963-976, doi: 10.1002/mds.28424.
Zimmermann M, Köhler L, Kovarova M, Lerche S, Schulte C, Wurster I, Machetanz G, Deuschle C, Hauser AK, Gasser T, Berg D, Schleicher E, Maetzler W, Brockmann K (2021), The longevity gene Klotho and its cerebrospinal fluid protein profiles as a modifier for Parkinson´s disease. European journal of neurology 28(5), 1557-1565, doi: 10.1111/ene.14733.
Langer A, Gassner L, Flotz A, Hasenauer S, Gruber J, Wizany L, Pokan R, Maetzler W, Zach H (2021), How COVID-19 will boost remote exercise-based treatment in Parkinson’s disease: a narrative review. npj Parkinson's disease 7(1), 25, doi: 10.1038/s41531-021-00160-3.
Kessler C, Serna-Higuita LM, Rattay TW, Maetzler W, Wurster I, Hayer S, Wilke C, Hengel H, Reichbauer J, Armbruster M, Schöls L, Martus P, Schüle R (2021), Neurofilament light chain is a cerebrospinal fluid biomarker in hereditary spastic paraplegia. Annals of clinical and translational neurology 8(5), 1122-1131, doi: 10.1002/acn3.51358.
Hansen C, Beckbauer M, Romijnders R, Warmerdam E, Welzel J, Geritz J, Emmert K, Maetzler W (2021), Reliability of imu-derived static balance parameters in neurological diseases. International journal of environmental research and public health 18(7), 3644, doi: 10.3390/ijerph18073644.
Blum L, Rosenbaum D, Röben B, Dehnen K, Maetzler W, Suenkel U, Fallgatter AJ, Ehlis AC, Metzger FG (2021), Age-related deterioration of performance and increase of cortex activity comparing time- versus item-controlled fNIRS measurement. Scientific reports 11(1), 6766, doi: 10.1038/s41598-021-85762-w.
Welzel J, Wendtland D, Warmerdam E, Romijnders R, Elshehabi M, Geritz J, Berg D, Hansen C, Maetzler W (2021), Step length is a promising progression marker in parkinson’s disease. Sensors 21(7), 2292, doi: 10.3390/s21072292.
Lerche S, Schulte C, Wurster I, Machetanz G, Roeben B, Zimmermann M, Deuschle C, Hauser AK, Böhringer J, Krägeloh-Mann I, Waniek K, Lachmann I, Petterson XMT, Chiang R, Park H, Wang B, Liepelt-Scarfone I, Maetzler W, Galasko D, Scherzer CR, Gasser T, Mielke MM, Hutten SJ, Mollenhauer B, Sardi SP, Berg D, Brockmann K (2021), The Mutation Matters: CSF Profiles of GCase, Sphingolipids, α-Synuclein in PDGBA. Movement Disorders 36(5), 1216-1228, doi: 10.1002/mds.28472.
Moitinho-Silva L, Wegener M, May S, Schrinner F, Akhtar A, Boysen TJ, Schaeffer E, Hansen C, Schmidt T, Rühlemann MC, Hübenthal M, Rausch P, Kondakci MT, Maetzler W, Weidinger S, Laudes M, Süß P, Schulte D, Junker R, Sommer F, Weisser B, Bang C, Franke A (2021), Short-term physical exercise impacts on the human holobiont obtained by a randomised intervention study. BMC microbiology 21(1), 162, doi: 10.1186/s12866-021-02214-1.
Völter C, Thomas JP, Maetzler W, Guthoff R, Grunwald M, Hummel T (2021), Sensory Dysfunction in Old Age. Deutsches Arzteblatt international 118(29-30), 512-520, doi: 10.3238/ARZTEBL.M2021.0212.
Corrà MF, Atrsaei A, Sardoreira A, Hansen C, Aminian K, Correia M, Vila-Chã N, Maetzler W, Maia L (2021), Comparison of laboratory and daily-life gait speed assessment during on and off states in parkinson’s disease. Sensors 21(12), 3974, doi: 10.3390/S21123974.
Langer A, Hasenauer S, Flotz A, Gassner L, Pokan R, Dabnichki P, Wizany L, Gruber J, Roth D, Zimmel S, Treven M, Schmoeger M, Willinger U, Maetzler W, Zach H (2021), A randomised controlled trial on effectiveness and feasibility of sport climbing in Parkinson’s disease. npj Parkinson's disease 7(1), 49, doi: 10.1038/S41531-021-00193-8.
Pilotto A, Rizzetti MC, Lombardi A, Hansen C, Biggi M, Verzeroli G, Martinelli A, Romijnders R, Borroni B, Maetzler W, Padovani A (2021), Cerebellar rTMS in PSP: a Double-Blind Sham-Controlled Study Using Mobile Health Technology. Cerebellum 20(4), 662-666, doi: 10.1007/S12311-021-01239-6.
Schaeffer E, Vaterrodt T, Zaunbrecher L, Liepelt-Scarfone I, Emmert K, Roeben B, Elshehabi M, Hansen C, Becker S, Nussbaum S, Busch JH, Synofzik M, Berg D, Maetzler W (2021), Effects of Levodopa on quality of sleep and nocturnal movements in Parkinson’s Disease. Journal of Neurology 268(7), 2506-2514, doi: 10.1007/S00415-021-10419-7.
Polhemus A, Ortiz LD, Brittain G, Chynkiamis N, Salis F, Gaßner H, Gross M, Kirk C, Rossanigo R, Taraldsen K, Balta D, Breuls S, Buttery S, Cardenas G, Endress C, Gugenhan J, Keogh A, Kluge F, Koch S, Micó-Amigo ME, Nerz C, Sieber C, Williams P, Bergquist R, de Basea MB, Buckley E, Hansen C, Mikolaizak AS, Schwickert L, Scott K, Stallforth S, van Uem J, Vereijken B, Cereatti A, Demeyer H, Hopkinson N, Maetzler W, Troosters T, Vogiatzis I, Yarnall A, Becker C, Garcia-Aymerich J, Leocani L, Mazzà C, Rochester L, Sharrack B, Frei A, Puhan M, Mobilise-D (2021), Walking on common ground: a cross-disciplinary scoping review on the clinical utility of digital mobility outcomes. NPJ digital medicine 4(1), 149, doi: 10.1038/s41746-021-00513-5.
Binder T, Hobert MA, Pfrommer T, Leks E, Granert O, Weigl B, Ethofer T, Erb M, Wilke M, Maetzler W, Berg D (2021), Increased functional connectivity in a population at risk of developing Parkinson's disease. Parkinsonism & related disorders 92, 1-6, doi: 10.1016/j.parkreldis.2021.09.026.
Mainka S, Schroll A, Warmerdam E, Gandor F, Maetzler W, Ebersbach G (2021), The Power of Musification: Sensor-Based Music Feedback Improves Arm Swing in Parkinson's Disease. Movement disorders clinical practice 8(8), 1240-1247, doi: 10.1002/mdc3.13352.
Warmerdam E, Romijnders R, Hansen C, Elshehabi M, Zimmermann M, Metzger FG, von Thaler AK, Berg D, Schmidt G, Maetzler W (2021), Arm swing responsiveness to dopaminergic medication in Parkinson's disease depends on task complexity. NPJ Parkinson's disease 7(1), 89, doi: 10.1038/S41531-021-00235-1.
Warmerdam E, Romijnders R, Geritz J, Elshehabi M, Maetzler C, Otto JC, Reimer M, Stuerner K, Baron R, Paschen S, Beyer T, Dopcke D, Eiken T, Ortmann H, Peters F, von der Recke F, Riesen M, Rohwedder G, Schaade A, Schumacher M, Sondermann A, Maetzler W, Hansen C (2021), Proposed Mobility Assessments with Simultaneous Full-Body Inertial Measurement Units and Optical Motion Capture in Healthy Adults and Neurological Patients for Future Validation Studies: Study Protocol. Sensors (Basel, Switzerland) 21(17), 5833, doi: 10.3390/S21175833.
Maetzler W, Pilotto A (2021), Digital assessment at home - mPower against Parkinson disease. Nature reviews. Neurology 17(11), 661-662, doi: 10.1038/S41582-021-00567-9.
Hoffmann J, Elzenheimer E, Bald C, Hansen C, Maetzler W, Schmidt G (2021), Active Magnetoelectric Motion Sensing: Examining Performance Metrics with an Experimental Setup. Sensors 21(23), 8000, doi: 10.3390/S21238000.
Mazzà C, Alcock L, Aminian K, Becker C, Bertuletti S, Bonci T, Brown P, Brozgol M, Buckley E, Carsin A-E, Caruso M, Caulfield B, Cereatti A, Chiari L, Chynkiamis N, Ciravegna F, Del Din S, Eskofier B, Evers J, Garcia Aymerich J, Gazit E, Hansen C, Hausdorff JM, Helbostad JL, Hiden H, Hume E, Paraschiv-Ionescu A, Ireson N, Keogh A, Kirk C, Kluge F, Koch S, Küderle A, Lanfranchi V, Maetzler W, Micó-Amigo ME, Mueller A, Neatrour I, Niessen M, Palmerini L, Pluimgraaff L, Reggi L, Salis F, Schwickert L, Scott K, Sharrack B, Sillen H, Singleton D, Soltani A, Taraldsen K, Ullrich M, Van Gelder L, Vereijken B, Vogiatzis I, Warmerdam E, Yarnall A, Rochester L (2021), Technical validation of real-world monitoring of gait: a multicentric observational study. BMJ Open 11(12), e050785, doi: 10.1136/BMJOPEN-2021-050785.
Stuendl A, Kraus T, Chatterjee M, Zapke B, Sadowski B, Moebius W, Hobert MA, Deuschle C, Brockmann K, Maetzler W, Mollenhauer B, Schneider A (2021), α-Synuclein in Plasma-Derived Extracellular Vesicles Is a Potential Biomarker of Parkinson's Disease. Movement disorders : official journal of the Movement Disorder Society 36(11), 2508-2518, doi: 10.1002/MDS.28639.
Atrsaei A, Hansen C, Elshehabi M, Solbrig S, Berg D, Liepelt-Scarfone I, Maetzler W, Aminian K (2021), Effect of Fear of Falling on Mobility Measured During Lab and Daily Activity Assessments in Parkinson's Disease. Frontiers in aging neuroscience 13, 722830, doi: 10.3389/fnagi.2021.722830.
Renno-Busch S, Hildesheim H, van Uem JMT, Sünkel U, Röben B, Brockmann K, Mychajliw C, Eschweiler GW, Berg D, Maetzler W (2021), Autonomic Symptoms in Older Adults Are Common and Associated With Health-Related Quality of Life. Frontiers in neurology 12, 757748, doi: 10.3389/fneur.2021.757748.
Zimmermann M, Wurster I, Lerche S, Roeben B, Machetanz G, Sünkel U, von Thaler A-K, Eschweiler G, Fallgatter AJ, Maetzler W, Berg D, Brockmann K (2020), Orthostatic hypotension as a risk factor for longitudinal deterioration of cognitive function in the elderly. European journal of neurology 27(1), 160-167, doi: 10.1111/ene.14050.
Geritz J, Maetzold S, Steffen M, Pilotto A, Corrà MF, Moscovich M, Rizzetti MC, Borroni B, Padovani A, Alpes A, Bang C, Barcellos I, Baron R, Bartsch T, Becktepe JS, Berg D, Bergeest LM, Bergmann P, Bouça-Machado R, Drey M, Elshehabi M, Farahmandi S, Ferreira JJ, Franke A, Friederich A, Geisler C, Hüllemann P, Gierthmühlen J, Granert O, Heinzel S, Heller MK, Hobert MA, Hofmann M, Jemlich B, Kerkmann L, Knüpfer S, Krause K, Kress M, Krupp S, Kudelka J, Kuhlenbäumer G, Kurth R, Leypoldt F, Maetzler C, Maia LF, Moewius A, Neumann P, Niemann K, Ortlieb CT, Paschen S, Pham MH, Puehler T, Radloff F, Riedel C, Rogalski M, Sablowsky S, Schanz EM, Schebesta L, Schicketmüller A, Studt S, Thieves M, Tönges L, Ullrich S, Urban PP, Vila-Chã N, Wiegard A, Warmerdam E, Warnecke T, Weiss M, Welzel J, Hansen C, Maetzler W (2020), Motor, cognitive and mobility deficits in 1000 geriatric patients: protocol of a quantitative observational study before and after routine clinical geriatric treatment - the ComOn-study. BMC geriatrics 20(1), 45, doi: 10.1186/s12877-020-1445-z.
Becker S, Bäumer A, Maetzler W, Nussbaum S, Timmers M, Van Nueten L, Salvadore G, Zaunbrecher D, Roeben B, Brockmann K, Streffer J, Berg D, Liepelt-Scarfone I (2020), Assessment of cognitive-driven activity of daily living impairment in non-demented Parkinson's patients. Journal of neuropsychology 14(1), 69-84, doi: 10.1111/jnp.12173.
Lerche S, Wurster I, Roeben B, Zimmermann M, Riebenbauer B, Deuschle C, Hauser AK, Schulte C, Berg D, Maetzler W, Waniek K, Lachmann I, Liepelt-Scarfone I, Gasser T, Brockmann K (2020), Parkinson's Disease: Glucocerebrosidase 1 Mutation Severity Is Associated with CSF Alpha-Synuclein Profiles. Movement disorders 35(3), 495-499, doi: 10.1002/mds.27884.
Krenovsky JP, Bötzel K, Ceballos-Baumann A, Fietzek UM, Schoser B, Maetzler W, Ferrari U, Drey M (2020), Interrelation between Sarcopenia and the Number of Motor Neurons in Patients with Parkinsonian Syndromes. Gerontology 66(4), 409-415, doi: 10.1159/000505590.
Fehlmann T, Kahraman M, Ludwig N, Backes C, Galata V, Keller V, Geffers L, Mercaldo N, Hornung D, Weis T, Kayvanpour E, Abu-Halima M, Deuschle C, Schulte C, Suenkel U, Von Thaler A-K, Maetzler W, Herr C, Fähndrich S, Vogelmeier P, Guimaraes P, Hecksteden A, Meyer T, Metzger F, Diener C, Deutscher S, Abdul-Khaliq H, Stehle I, Haeusler S, Meiser A, Groesdonk HV, Volk T, Lenhof HP, Katus H, Balling R, Meder B, Kruger R, Huwer H, Bals R, Meese E, Keller A (2020), Evaluating the Use of Circulating MicroRNA Profiles for Lung Cancer Detection in Symptomatic Patients. JAMA oncology 6(5), 714-723, doi: 10.1001/jamaoncol.2020.0001.
Warmerdam E, Hausdorff JM, Atrsaei A, Zhou Y, Mirelman A, Aminian K, Espay AJ, Hansen C, Evers LJW, Keller A, Lamoth C, Pilotto A, Rochester L, Schmidt G, Bloem BR, Maetzler W (2020), Long-term unsupervised mobility assessment in movement disorders. The lancet neurology 19(5), 462-470, doi: 10.1016/S1474-4422(19)30397-7.
Zhou Y, Romijnders R, Hansen C, van Campen J, Maetzler W, Hortobágyi T, Lamoth CJC (2020), The detection of age groups by dynamic gait outcomes using machine learning approaches. Scientific reports 10(1), 1-12, doi: 10.1038/s41598-020-61423-2.
Becker S, Bäumer A, Maetzler W, Nussbaum S, Tkaczynska Z, Sulzer P, Timmers M, van Nueten L, Salvadore G, Brockmann K, Streffer J, Berg D, Liepelt-Scarfone I (2020), Association of Cognitive Activities of Daily Living (ADL) Function and Nonmotor Burden in Nondemented Parkinson's Disease Patients. Neuropsychology 34(4), 447-455, doi: 10.1037/neu0000627.
Morgan C, Rolinski M, McNaney R, Jones B, Rochester L, Maetzler W, Craddock I, Whone AL (2020), Systematic Review Looking at the Use of Technology to Measure Free-Living Symptom and Activity Outcomes in Parkinson's Disease in the Home or a Home-like Environment. Journal of Parkinson's disease 10(2), 429-454, doi: 10.3233/JPD-191781.
Hopfner F, Mueller SH, Szymczak S, Junge O, Tittmann L, May S, Lohmann K, Grallert H, Lieb W, Strauch K, Müller-Nurasyid M, Berger K, Schormair B, Winkelmann J, Mollenhauer B, Trenkwalder C, Maetzler W, Berg D, Kasten M, Klein C, Höglinger GU, Gasser T, Deuschl G, Franke A, Krawczak M, Dempfle A, Kuhlenbäumer G (2020), Rare Variants in Specific Lysosomal Genes Are Associated With Parkinson's Disease. Movement disorders 35(7), 1245-1248, doi: 10.1002/mds.28037.
Wilke C, dos Santos MCT, Schulte C, Deuschle C, Scheller D, Verbelen M, Brockmann K, von Thaler A-K, Sünkel U, Roeben B, Bujac S, Metzger FG, Maetzler W, Nogueira da Costa A, Synofzik M, Berg D (2020), Intraindividual Neurofilament Dynamics in Serum Mark the Conversion to Sporadic Parkinson's Disease. Movement disorders 35(7), 1233-1238, doi: 10.1002/mds.28026.
Jacobs AH, Emmert K, Baron R, Bartsch T, Bauer J, Becker C, Berg D, Bergmann P, Boetzel K, Bollheimer C, Deuschl G, Djukic M, Drey M, Durwen H, Ebersbach G, Elshehabi M, Geritz J, Gisinger C, Guennewig T, Hauptmann B, Heppner HJ, Hobert MA, Hofmann W, Huellemann P, Jahn K, Klucken J, Kurth R, Lindner R, Lingor P, Lukas A, Maetzold S, Mokrusch T, Mollenhauer B, Nau R, Plate A, Polidori MC, Prell T, Schellinger P, Spira D, Stephani U, Studt S, Trenkwalder C, Unger HL, Urban P, von Arnim CAF, Warnecke T, Weiss M, Wiedemann A, Wirth R, Witt K, Dodel R, Maetzler W (2020), Neurogeriatrics—a vision for improved care and research for geriatric patients with predominating neurological disabilities. Zeitschrift für Gerontologie und Geriatrie 53(4), 340-346, doi: 10.1007/s00391-020-01734-1.
Hopfner F, Mueller SH, Szymczak S, Junge O, Tittmann L, May S, Lohmann K, Grallert H, Lieb W, Strauch K, Müller-Nurasyid M, Berger K, Schormair B, Winkelmann J, Mollenhauer B, Trenkwalder C, Maetzler W, Berg D, Kasten M, Klein C, Höglinger HU, Gasser T, Deuschl G, Franke A, Krawczak M, Dempfle A, Kuhlenbäumer G (2020), Private variants in PRKN are associated with late-onset Parkinson's disease. Parkinsonism & related disorders 75, 24-26, doi: 10.1016/j.parkreldis.2020.05.003.
Atrsaei A, Dadashi F, Hansen C, Warmerdam E, Mariani B, Maetzler W, Aminian K (2020), Postural transitions detection and characterization in healthy and patient populations using a single waist sensor. Journal of neuroengineering and rehabilitation 17(1), 1-14, doi: 10.1186/s12984-020-00692-4.
Baldini F, Hertel J, Sandt E, Thinnes CC, Neuberger-Castillo L, Pavelka L, Betsou F, Krüger R, Thiele I (2020), Parkinson's disease-associated alterations of the gut microbiome predict disease-relevant changes in metabolic functions. BMC biology 18(1), 62, doi: 10.1186/s12915-020-00775-7.
Hobert MA, Maetzler W, Schlenstedt C (2020), Does increased forefoot load contribute to freezing of gait in Parkinson's disease? A clinical observation. Parkinsonism & related disorders 77, 83-84, doi: 10.1016/j.parkreldis.2020.06.021.
Zhou Y, Rehman RZU, Hansen C, Maetzler W, del Din S, Rochester L, Hortobágyi T, Lamoth CJC (2020), Classification of neurological patients to identify fallers based on spatial-temporal gait characteristics measured by a wearable device. Sensors 20(15), 1-15, doi: 10.3390/s20154098.
Willmann C, Brockmann K, Wagner R, Kullmann S, Preissl H, Schnauder G, Maetzler W, Gasser T, Berg D, Eschweiler GW, Metzger F, Fallgatter AJ, Häring H-U, Fritsche A, Heni M (2020), Insulin sensitivity predicts cognitive decline in individuals with prediabetes. BMJ open diabetes research & care 8(2), e001741, doi: 10.1136/bmjdrc-2020-001741.
Hobert MA, Hofmann W, Bartsch T, Peters S, Maetzler W (2020), Diagnosis and treatment of vascular dementia. Zeitschrift für Gerontologie und Geriatrie 53(7), 687-698, doi: 10.1007/s00391-020-01786-3.
Viceconti M, Penna SH, Dartee W, Mazzà C, Caulfield B, Becker C, Maetzler W, Garcia-Aymerich J, Davico G, Rochester L (2020), Toward a regulatory qualification of real-world mobility performance biomarkers in parkinson’s patients using digital mobility outcomes. Sensors 20(20), 1-13, doi: 10.3390/s20205920.
Alzaid H, Ethofer T, Hobert MA, Kardatzki B, Erb M, Maetzler W, Berg D (2020), Distinct Relationship Between Cognitive Flexibility and White Matter Integrity in Individuals at Risk of Parkinson’s Disease. Frontiers in aging neuroscience 12, 250, doi: 10.3389/fnagi.2020.00250.
Warmerdam E, Romijnders R, Welzel J, Hansen C, Schmidt G, Maetzler W (2020), Quantification of arm swing during walking in healthy adults and parkinson’s disease patients: Wearable sensor-based algorithm development and validation. Sensors 20(20), 1-12, doi: 10.3390/s20205963.
Tkaczynska Z, Becker S, Maetzler W, Timmers M, Van Nueten L, Sulzer P, Salvadore G, Schäffer E, Brockmann K, Streffer J, Berg D, Liepelt-Scarfone I (2020), Executive Function Is Related to the Urinary Urgency in Non-demented Patients With Parkinson’s Disease. Frontiers in aging neuroscience 12, 55, doi: 10.3389/fnagi.2020.00055.
Polhemus AM, Bergquist R, Bosch De Basea M, Brittain G, Buttery SC, Chynkiamis N, Dalla Costa G, Delgado Ortiz L, Demeyer H, Emmert K, Garcia Aymerich J, Gassner H, Hansen C, Hopkinson N, Klucken J, Kluge F, Koch S, Leocani L, Maetzler W, Micó-Amigo ME, Mikolaizak AS, Piraino P, Salis F, Schlenstedt C, Schwickert L, Scott K, Sharrack B, Taraldsen K, Troosters T, Vereijken B, Vogiatzis I, Yarnall A, Mazza C, Becker C, Rochester L, Puhan MA, Frei A (2020), Walking-related digital mobility outcomes as clinical trial endpoint measures: Protocol for a scoping review. BMJ open 10(7), e038704, doi: 10.1136/bmjopen-2020-038704.
Heinzel S, Aho VTE, Suenkel U, von Thaler A-K, Schulte C, Deuschle C, Paulin L, Hantunen S, Brockmann K, Eschweiler GW, Maetzler W, Berg D, Auvinen P, Scheperjans F (2020), Gut Microbiome Signatures of Risk and Prodromal Markers of Parkinson Disease. Annals of neurology 88(2), 320-331, doi: 10.1002/ana.25788.
Rehman RZU, Zhou Y, Del Din S, Alcock L, Hansen C, Guan Y, Hortobágyi T, Maetzler W, Rochester L, Lamoth CJC (2020), Gait analysis with wearables can accurately classify fallers from non-fallers: A step toward better management of neurological disorders. Sensors 20(23), 1-17, doi: 10.3390/s20236992.
Corrà MF, Warmerdam E, Vila-Chã N, Maetzler W, Maia L (2020), Wearable health technology to quantify the functional impact of peripheral neuropathy on mobility in Parkinson’s disease: A systematic review. Sensors 20(22), 1-34, doi: 10.3390/s20226627.
Fehlmann T, Lehallier B, Schaum N, Hahn O, Kahraman M, Li Y, Grammes N, Geffers L, Backes C, Balling R, Kern F, Krüger R, Lammert F, Ludwig N, Meder B, Fromm B, Maetzler W, Berg D, Brockmann K, Deuschle C, von Thaler AK, Eschweiler GW, Milman S, Barziliai N, Reichert M, Wyss-Coray T, Meese E, Keller A (2020), Common diseases alter the physiological age-related blood microRNA profile. Nature communications 11(1), 5958, doi: 10.1038/s41467-020-19665-1.
Morgan C, Craddock I, Tonkin EL, Kinnunen KM, Mcnaney R, Whitehouse S, Mirmehdi M, Heidarivincheh F, Mcconville R, Carey J, Horne A, Rolinski M, Rochester L, Maetzler W, Matthews H, Watson O, Eardley R, Whone AL (2020), Protocol for PD SENSORS: Parkinson's Disease Symptom Evaluation in a Naturalistic Setting producing Outcome measuRes using SPHERE technology. An observational feasibility study of multi-modal multi-sensor technology to measure symptoms and activities of d. BMJ open 10(11), e041303, doi: 10.1136/bmjopen-2020-041303.
Monje MHG, Fuller RLM, Cubo E, Mestre TA, Tan AH, Stout JC, Ali S, Chahine L, Dujardin K, Fitzer-Attas CJ, Youn J, Bloem BR, Horak FB, Merola A, Reilmann R, Paul SS, Dorsey ER, Maetzler W, Espay AJ, Martinez-Martin P, Stebbins GT, Sánchez-Ferro Á (2020), Toward e-Scales: Digital Administration of the International Parkinson and Movement Disorder Society Rating Scales. Movement Disorders Clinical Practice 8(2), 208-214, doi: 10.1002/mdc3.13135.
Artusi CA, Imbalzano G, Sturchio A, Pilotto A, Montanaro E, Padovani A, Lopiano L, Maetzler W, Espay AJ (2020), Implementation of Mobile Health Technologies in Clinical Trials of Movement Disorders: Underutilized Potential. Neurotherapeutics 17(4), 1736-1746, doi: 10.1007/s13311-020-00901-x.
Lerche S, Wurster I, Röben B, Machetanz G, Zimmermann M, Bernhard F, Stransky E, Deuschle C, Schulte C, Hansson O, Zetterberg H, Gasser T, Berg D, Maetzler W, Brockmann K (2019), Parkinson's disease: evolution of cognitive impairment and CSF Aβ1-42 profiles in a prospective longitudinal study. Journal of neurology, neurosurgery, and psychiatry 90(2), 165-170, doi: 10.1136/jnnp-2018-318956.
Friederich A, Flinspach A, Suenkel U, Eschweiler GW, Greulich K, Maetzler W, Berg D, Heinzel S (2019), Prodromal features of Parkinson's disease: Self-reported symptoms versus clinically assessed signs. Movement disorders 34(1), 144-146, doi: 10.1002/mds.27539.
Micó-Amigo ME, Kingma I, Heinzel S, Rispens SM, Heger T, Nussbaum S, van Lummel RC, Berg D, Maetzler W, van Dieën JH (2019), Potential Markers of Progression in Idiopathic Parkinson’s Disease Derived From Assessment of Circular Gait With a Single Body-Fixed-Sensor: A 5 Year Longitudinal Study. Frontiers in human neuroscience 13, 59, doi: 10.3389/fnhum.2019.00059.
Hobert MA, Nussbaum S, Heger T, Berg D, Maetzler W, Heinzel S (2019), Progressive Gait Deficits in Parkinson's Disease: A Wearable-Based Biannual 5-Year Prospective Study. Frontiers in aging neuroscience 11, 22, doi: 10.3389/fnagi.2019.00022.
Hobert MA, Bernhard FP, Bettecken K, Sartor J, Maetzler W, Jamour M (2019), [Validation of the Geriatric Check in a cohort of hospitalized neurological patients]. Zeitschrift für Gerontologie und Geriatrie 52(2), 172-178, doi: 10.1007/s00391-018-1441-5.
Brittain C, McCarthy A, Irizarry MC, McDermott D, Biglan K, Höglinger GU, Lorenzl S, del Ser T, Boxer AL, AL-108-231, 4RTNI TAUROS and PROPSPERA investigators (2019), Severity dependent distribution of impairments in PSP and CBS: Interactive visualizations. Parkinsonism & related disorders 60, 138-145, doi: 10.1016/j.parkreldis.2018.08.025.
Srulijes K, Klenk J, Schwenk M, Schatton C, Schwickert L, Teubner-Liepert K, Meyer M, K C S, Maetzler W, Becker C, Synofzik M (2019), Fall Risk in Relation to Individual Physical Activity Exposure in Patients with Different Neurodegenerative Diseases: a Pilot Study. Cerebellum 18(3), 340-348, doi: 10.1007/s12311-018-1002-x.
Espay AJ, Hausdorff JM, Sánchez-Ferro A, Klucken J, Merola A, Bonato P, Paul SS, Horak FB, Vizcarra JA, Mestre TA, Reilmann R, Nieuwboer A, Dorsey ER, Rochester L, Bloem BR, Maetzler W, Movement Disorder Society Task Force on Technology (2019), A roadmap for implementation of patient-centered digital outcome measures in Parkinson's disease obtained using mobile health technologies. Movement disorders 34(5), 657-663, doi: 10.1002/mds.27671.
Del Din S, Elshehabi M, Galna B, Hobert MA, Warmerdam E, Suenkel U, Brockmann K, Metzger F, Hansen C, Berg D, Rochester L, Maetzler W (2019), Gait analysis with wearables predicts conversion to parkinson disease. Annals of neurology 86(3), 357-367, doi: 10.1002/ana.25548.
Mätzold S, Geritz J, Zeuner KE, Berg D, Paschen S, Hieke J, Sablowsky S, Ortlieb C, Bergmann P, Hofmann W, Espay AJ, Maetzler W (2019), Functional movement disorders in neurogeriatric inpatients : Underdiagnosed, often comorbid to neurodegenerative disorders and treatable. Zeitschrift für Gerontologie und Geriatrie 52(4), 324-329, doi: 10.1007/s00391-019-01562-y.
Lerche S, Machetanz G, Wurster I, Roeben B, Zimmermann M, Pilotto A, Preische O, Stransky E, Deuschle C, Hauser A-K, Schulte C, Lachmann I, Waniek K, Gasser T, Berg D, Maetzler W, Brockmann K (2019), Dementia with lewy bodies: GBA1 mutations are associated with cerebrospinal fluid alpha‐synuclein profile. Movement disorders 34(7), 1069-1073, doi: 10.1002/mds.27731.
Lieb W, Jacobs G, Wolf A, Richter G, Gaede KI, Schwarz J, Arnold N, Böhm R, Buyx A, Cascorbi I, Franke A, Glinicke C, Held-Feindt J, Junker R, Kalthoff H, Kramer H-H, Leypoldt F, Maass N, Maetzler W, May S, Mehdorn HM, Röcken C, Schafmayer C, Schrappe M, Schreiber S, Sebens S, Stephani U, Synowitz M, Weimer J, Zabel P, Nöthlings U, Röder C, Krawczak M (2019), Linking pre-existing biorepositories for medical research: the PopGen 2.0 Network. Journal of community genetics 10(4), 523-530, doi: 10.1007/s12687-019-00417-8.
Maetzler W, Del Din S, Elshehabi M, Galna B, Berg D, Rochester L (2019), Reply to "Quantitative Motor Functioning in Prodromal Parkinson Disease". Annals of neurology 86(6), 981-982, doi: 10.1002/ana.25605.
Jain G, Stuendl A, Rao P, Berulava T, Pena Centeno T, Kaurani L, Burkhardt S, Delalle I, Kornhuber J, Hüll M, Maier W, Peters O, Esselmann H, Schulte C, Deuschle C, Synofzik M, Wiltfang J, Mollenhauer B, Maetzler W, Schneider A, Fischer A (2019), A combined miRNA-piRNA signature to detect Alzheimer's disease. Translational psychiatry 9(1), 250, doi: 10.1038/s41398-019-0579-2.
Nissen SK, Shrivastava K, Schulte C, Otzen DE, Goldeck D, Berg D, Møller HJ, Maetzler W, Romero-Ramos M (2019), Alterations in Blood Monocyte Functions in Parkinson's Disease. Movement disorders 34(11), 1711-1721, doi: 10.1002/mds.27815.
Schaeffer E, Busch F-H, Roeben B, Otterbein S, Saraykin P, Leks E, Liepelt-Scarfone I, Synofzik M, Elshehabi M, Maetzler W, Hansen C, Andris S, Berg D (2019), Effects of Exergaming on Attentional Deficits and Dual-Tasking in Parkinson's Disease. Frontiers in neurology 10, 646, doi: 10.3389/fneur.2019.00646.
Hopfner F, Hobert MA, Maetzler C, Hansen C, Pham MH, Moreau C, Berg D, Devos D, Maetzler W, Fair-Park II study group (2019), Mobility Deficits Assessed With Mobile Technology: What Can We Learn From Brain Iron-Altered Animal Models? Frontiers in neurology 10, 833, doi: 10.3389/fneur.2019.00833.
Badawy R, Hameed F, Bataille L, Little MA, Claes K, Saria S, Cedarbaum JM, Stephenson D, Neville J, Maetzler W, Espay AJ, Bloem BR, Simuni T, Karlin DR (2019), Metadata Concepts for Advancing the Use of Digital Health Technologies in Clinical Research. Digital biomarkers 3(3), 116-132, doi: 10.1159/000502951.
Merchant KM, Cedarbaum JM, Brundin P, Dave KD, Eberling J, Espay AJ, Hutten SJ, Javidnia M, Luthman J, Maetzler W, Menalled L, Reimer AN, Stoessl AJ, Weiner DM (2019), A proposed roadmap for Parkinson's disease proof of concept clinical trials investigating compounds targeting alpha-synuclein. Journal of Parkinson's disease 9(1), 31-61, doi: 10.3233/JPD-181471.
Micó-Amigo ME, Kingma I, Heinzel S, Nussbaum S, Heger T, van Lummel RC, Berg D, Maetzler W, van Dieën JH (2019), Dual vs. Single Tasking During Circular Walking: What Better Reflects Progression in Parkinson's Disease? Frontiers in neurology 10, 372, doi: 10.3389/fneur.2019.00372.
Goodall G, Ciobanu I, Taraldsen K, Sørgaard J, Marin A, Draghici R, Zamfir MV, Berteanu M, Maetzler W, Serrano JA (2019), The use of virtual and immersive technology in creating personalized multisensory spaces for people living with dementia (sense-garden): Protocol for a multisite before-after trial. JMIR research protocols 8(9), e14096, doi: 10.2196/14096.
Ludwig N, Fehlmann T, Kern F, Gogol M, Maetzler W, Deutscher S, Gurlit S, Schulte C, von Thaler AK, Deuschle C, Metzger F, Berg D, Suenkel U, Keller V, Backes C, Lenhof HP, Meese E, Keller A (2019), Machine Learning to Detect Alzheimer's Disease from Circulating Non-coding RNAs. Genomics, proteomics and bioinformatics 17(4), 430-440, doi: 10.1016/j.gpb.2019.09.004.
Vizcarra JA, Sánchez-Ferro Á, Maetzler W, Marsili L, Zavala L, Lang AE, Martinez-Martin P, Mestre TA, Reilmann R, Hausdorff JM, Dorsey ER, Paul SS, Dexheimer JW, Wissel BD, Fuller RLM, Bonato P, Tan AH, Bloem BR, Kopil C, Daeschler M, Bataille L, Kleiner G, Cedarbaum JM, Klucken J, Merola A, Goetz CG, Stebbins GT, Espay AJ, Committee MDSTTFMDSRSPEDA-H (2019), The Parkinson's disease e-diary: Developing a clinical and research tool for the digital age. Movement Disorders 34(5), 676-681, doi: 10.1002/mds.27673.
Kroneberg D, Elshehabi M, Meyer AC, Otte K, Doss S, Paul F, Nussbaum S, Berg D, Kühn AA, Maetzler W, Schmitz-Hübsch T (2019), Less is more - Estimation of the number of strides required to assess gait variability in spatially confined settings. Frontiers in Aging Neuroscience 10, 435, url, doi: 10.3389/fnagi.2018.00435.
Artusi CA, Mishra M, Latimer P, Vizcarra JA, Lopiano L, Maetzler W, Merola A, Espay AJ (2018), Integration of technology-based outcome measures in clinical trials of Parkinson and other neurodegenerative diseases. Parkinsonism & related disorders 46 Suppl 1, S53-S56, doi: 10.1016/j.parkreldis.2017.07.022.
Blauwendraat C, Wilke C, Simón-Sánchez J, Jansen IE, Reifschneider A, Capell A, Haass C, Castillo-Lizardo M, Biskup S, Maetzler W, Rizzu P, Heutink P, Synofzik M (2018), The wide genetic landscape of clinical frontotemporal dementia: systematic combined sequencing of 121 consecutive subjects. Genetics in medicine 20(2), 240-249, doi: 10.1038/gim.2017.102.
Maetzler W, Berg D (2018), Parkinson disease in 2017: Changing views after 200 years of Parkinson disease. Nature reviews neurology 14(2), 70-72, doi: 10.1038/nrneurol.2017.183.
van Uem JMT, Cerff B, Kampmeyer M, Prinzen J, Zuidema M, Hobert MA, Gräber S, Berg D, Maetzler W, Liepelt-Scarfone I (2018), The association between objectively measured physical activity, depression, cognition, and health-related quality of life in Parkinson's disease. Parkinsonism & related disorders 48, 74-81, doi: 10.1016/j.parkreldis.2017.12.023.
Lerche S, Gutfreund A, Brockmann K, Hobert MA, Wurster I, Sünkel U, Eschweiler GW, Metzger FG, Maetzler W, Berg F (2018), Effect of physical activity on cognitive flexibility, depression and RBD in healthy elderly. Clinical neurology and neurosurgery 165, 88-93, doi: 10.1016/j.clineuro.2018.01.008.
Geritz J, Maetzler W, Schlenstedt C (2018), [Influence of computer-based cognitive training on mobility in healthy older adults : A systematic review]. Zeitschrift für Gerontologie und Geriatrie 51(2), 184-192, doi: 10.1007/s00391-018-1369-9.
Bouça-Machado R, Maetzler W, Ferreira JJ (2018), What is Functional Mobility Applied to Parkinson’s Disease? Journal of Parkinson's disease 8(1), 121-130, doi: 10.3233/JPD-171233.
Schlenstedt C, Mancini M, Nutt J, Hiller AP, Maetzler W, Deuschl G, Horak F (2018), Are Hypometric Anticipatory Postural Adjustments Contributing to Freezing of Gait in Parkinson’s Disease? Frontiers in aging neuroscience 10, 36, doi: 10.3389/fnagi.2018.00036.
Haertner L, Elshehabi M, Zaunbrecher L, Pham MH, Maetzler C, van Uem JMT, Hobert MA, Hucker S, Nussbaum S, Berg D, Liepelt-Scarfone I, Maetzler W (2018), Effect of Fear of Falling on Turning Performance in Parkinson's Disease in the Lab and at Home. Frontiers in aging neuroscience 10, 78, doi: 10.3389/fnagi.2018.00078.
Stoessel D, Schulte C, Teixeira Dos Santos MC, Scheller D, Rebollo-Mesa I, Deuschle C, Walther D, Schauer N, Berg D, Nogueira da Costa A, Maetzler W (2018), Promising Metabolite Profiles in the Plasma and CSF of Early Clinical Parkinson's Disease. Frontiers in aging neuroscience 10, 51, doi: 10.3389/fnagi.2018.00051.
Roeben B, Zieschang T, Maetzler W (2018), [Therapy of Dementia: State of the Art]. Deutsche medizinische Wochenschrift (1946) 143(10), 741-747, doi: 10.1055/s-0043-113619.
Dos Santos MCT, Barreto-Sanz MA, Correia BRS, Bell R, Widnall C, Perez LT, Berteau C, Schulte C, Scheller D, Berg D, Maetzler W, Galante PAF, Nogueira da Costa A (2018), miRNA-based signatures in cerebrospinal fluid as potential diagnostic tools for early stage Parkinson's disease. Oncotarget 9(25), 17455-17465, doi: 10.18632/oncotarget.24736.
Stoessel D, Stellmann J-P, Willing A, Behrens B, Rosenkranz SC, Hodecker SC, Stürner KH, Reinhardt S, Fleischer S, Deuschle C, Maetzler W, Berg D, Heesen C, Walther D, Schauer N, Friese MA, Pless O (2018), Metabolomic Profiles for Primary Progressive Multiple Sclerosis Stratification and Disease Course Monitoring. Frontiers in human neuroscience 12, 226, doi: 10.3389/fnhum.2018.00226.
Ciliz M, Sartor J, Lindig T, Pilotto A, Schäffer E, Weiss M, Scheltens P, Becker S, Hobert MA, Berg D, Liepelt-Scarfone I, Maetzler W (2018), Brain-Area Specific White Matter Hyperintensities: Associations to Falls in Parkinson's Disease. Journal of Parkinson's disease 8(3), 455-462, doi: 10.3233/JPD-181351.
Heinzel S, Berg D, Binder S, Ebersbach G, Hickstein L, Herbst H, Lorrain M, Wellach I, Maetzler W, Petersen G, Schmedt N, Volkmann J, Woitalla D, Amelung V (2018), Do We Need to Rethink the Epidemiology and Healthcare Utilization of Parkinson's Disease in Germany? Frontiers in neurology 9, 500, doi: 10.3389/fneur.2018.00500.
Bernhard FP, Sartor J, Bettecken K, Hobert MA, Arnold C, Weber YG, Poli W, Margraf NG, Schlenstedt C, Hansen C, Maetzler W (2018), Wearables for gait and balance assessment in the neurological ward - study design and first results of a prospective cross-sectional feasibility study with 384 inpatients. BMC neurology 18(1), 114, doi: 10.1186/s12883-018-1111-7.
Lerche S, Machetanz G, Roeben B, Wurster I, Zimmermann M, von Thaler A-K, Liepelt-Scarfone I, Eschweiler GW, Fallgatter A, Metzger F, Maetzler W, Berg D, Brockmann K (2018), Deterioration of executive dysfunction in elderly with REM sleep behavior disorder (RBD). Neurobiology of aging 70, 242-246, doi: 10.1016/j.neurobiolaging.2018.06.029.
Körtvelyessy P, Prüss H, Thurner L, Maetzler W, Vittore-Welliong D, Schultze-Amberger J, Heinze H-J, Reinhold D, Leypoldt F, Schreiber S, Bittner D (2018), Biomarkers of Neurodegeneration in Autoimmune-Mediated Encephalitis. Frontiers in neurology 9, 668, doi: 10.3389/fneur.2018.00668.
Arnold C, Schulte C, Moscovich M, Sünkel U, Zaunbrecher L, Metzger F, Gasser T, Eschweiler GW, Hauser A-K, Berg D, Maetzler W (2018), Cholinergic Pathway SNPs and Postural Control in 477 Older Adults. Frontiers in aging neuroscience 10, 260, doi: 10.3389/fnagi.2018.00260.
Blum D, la Fougère C, Pilotto A, Maetzler W, Berg D, Reimold M, Liepelt-Scarfone I (2018), Hypermetabolism in the cerebellum and brainstem and cortical hypometabolism are independently associated with cognitive impairment in Parkinson's disease. European journal of nuclear medicine and molecular imaging 45(13), 2387-2395, doi: 10.1007/s00259-018-4085-1.
Killeen T, Elshehabi M, Filli L, Hobert MA, Hansen C, Rieger D, Brockmann K, Nussbaum S, Zörner B, Bolliger M, Curt A, Berg D, Maetzler W (2018), Arm swing asymmetry in overground walking. Scientific reports 8(1), 12803, doi: 10.1038/s41598-018-31151-9.
Sulzer P, Becker S, Maetzler W, Kalbe E, van Nueten L, Timmers M, Machetanz G, Streffer J, Salvadore G, Scholz E, Tkaczynska Z, Brockmann K, Berg D, Liepelt-Scarfone I (2018), Validation of a novel Montreal Cognitive Assessment scoring algorithm in non-demented Parkinson's disease patients. Journal of neurology 265(9), 1976-1984, doi: 10.1007/s00415-018-8942-4.
Lerche S, Liepelt-Scarfone I, Wurster I, Schulte C, Schäffer E, Röben B, Machetanz G, Zimmermann M, Akbas S, Hauser A-K, Gasser T, Maetzler W, Berg D, Brockmann K (2018), Polygenic load: Earlier disease onset but similar longitudinal progression in Parkinson's disease. Movement disorders 33(8), 1349-1353, doi: 10.1002/mds.27427.
Pham MH, Warmerdam E, Elshehabi M, Schlenstedt C, Bergeest L-M, Heller M, Haertner L, Ferreira JJ, Berg D, Schmidt G, Hansen C, Maetzler W (2018), Validation of a Lower Back "Wearable"-Based Sit-to-Stand and Stand-to-Sit Algorithm for Patients With Parkinson's Disease and Older Adults in a Home-Like Environment. Frontiers in neurology 9, 652, doi: 10.3389/fneur.2018.00652.
Schlenstedt C, Paschen S, Seuthe J, Raethjen J, Berg D, Maetzler W, Deuschl G (2018), Moderate Frequency Resistance and Balance Training Do Not Improve Freezing of Gait in Parkinson's Disease: A Pilot Study. Frontiers in neurology 9, 1084, doi: 10.3389/fneur.2018.01084.
Hansen C, Sanchez-Ferro A, Maetzler W (2018), How Mobile Health Technology and Electronic Health Records Will Change Care of Patients with Parkinson’s Disease. Journal of Parkinson's disease 8(s1), S41-S45, doi: 10.3233/JPD-181498.
Yilmaz R, Strafella AP, Bernard A, Schulte C, van den Heuvel L, Schneiderhan-Marra N, Knorpp T, Joos TO, Leypoldt F, Geritz J, Hansen C, Heinzel S, Apel A, Gasser T, Lang AE, Berg D, Maetzler W, Marras C (2018), Serum Inflammatory Profile for the Discrimination of Clinical Subtypes in Parkinson's Disease. Frontiers in neurology 9, 1123, doi: 10.3389/fneur.2018.01123.
Dos Santos MCT, Scheller D, Schulte C, Mesa IR, Colman P, Bujac SR, Bell R, Berteau C, Perez LT, Lachmann I, Berg D, Maetzler W, Nogueira da Costa A (2018), Evaluation of cerebrospinal fluid proteins as potential biomarkers for early stage Parkinson's disease diagnosis. PloS one 13(11), e0206536, doi: 10.1371/journal.pone.0206536.
Sartor J, Bettecken K, Bernhard FP, Hofmann M, Gladow T, Lindig T, Ciliz M, Ten Kate M, Geritz J, Heinzel S, Benedictus M, Scheltens P, Hobert MA, Maetzler W (2017), White Matter Changes-Related Gait and Executive Function Deficits: Associations with Age and Parkinson's Disease. Frontiers in aging neuroscience 9, 213, doi: 10.3389/fnagi.2017.00213.
Pilotto A, Heinzel S, Suenkel U, Lerche S, Brockmann K, Roeben B, Schaeffer E, Wurster I, Yilmaz R, Liepelt-Scarfone I, von Thaler A-K, Metzger FG, Eschweiler GW, Postuma RB, Maetzler W, Berg D (2017), Application of the movement disorder society prodromal Parkinson's disease research criteria in 2 independent prospective cohorts. Movement disorders 32(7), 1025-1034, doi: 10.1002/mds.27035.
Yilmaz R, Pilotto A, Roeben B, Preische O, Suenkel U, Heinzel S, Metzger FG, Laske C, Maetzler W, Berg D (2017), Structural Ultrasound of the Medial Temporal Lobe in Alzheimer's Disease. Ultraschall in der Medizin 38(3), 294-300, doi: 10.1055/s-0042-107150.
Hobert MA, Meyer SI, Hasmann SE, Metzger FG, Suenkel U, Eschweiler GW, Berg D, Maetzler W (2017), Gait Is Associated with Cognitive Flexibility: A Dual-Tasking Study in Healthy Older People. Frontiers in aging neuroscience 9, 154, doi: 10.3389/fnagi.2017.00154.
Brockmann K, Lerche S, Dilger SS, Stirnkorb JG, Apel A, Hauser AK, Liepelt-Scarfone I, Berg D, Gasser T, Schulte C, Maetzler W (2017), SNPs in Aβ clearance proteins: Lower CSF Aβ1-42levels and earlier onset of dementia in PD. Neurology 89(23), 2335-2340, doi: 10.1212/WNL.0000000000004705.
Bettecken K, Bernhard F, Sartor J, Hobert MA, Hofmann M, Gladow T, van Uem JMT, Liepelt-Scarfone I, Maetzler W (2017), No relevant association of kinematic gait parameters with Health-related Quality of Life in Parkinson's disease. PloS one 12(5), e0176816, doi: 10.1371/journal.pone.0176816.
Pham MH, Elshehabi M, Haertner L, Heger T, Hobert MA, Faber GS, Salkovic D, Ferreira JJ, Berg D, Sanchez-Ferro A, van Dieën JH, Maetzler W (2017), Algorithm for Turning Detection and Analysis Validated under Home-Like Conditions in Patients with Parkinson's Disease and Older Adults using a 6 Degree-of-Freedom Inertial Measurement Unit at the Lower Back. Frontiers in neurology 8, 135, doi: 10.3389/fneur.2017.00135.
Salkovic D, Hobert MA, Bellut C, Funer F, Renno S, Haertner L, Hasmann SE, Staebler J, Geritz J, Suenkel U, Fallgatter AJ, Eschweiler GW, Berg D, Maetzler W (2017), Evidence for a Selectively Regulated Prioritization Shift Depending on Walking Situations in Older Adults. Frontiers in aging neuroscience 9, 75, doi: 10.3389/fnagi.2017.00075.
Walter U, Zach H, Liepelt-Scarfone I, Maetzler W (2017), [Helpful instrumental examinations in idiopathic Parkinson's disease]. Der Nervenarzt 88(4), 365-372, doi: 10.1007/s00115-017-0289-z.
Zach H, Walter U, Liepelt-Scarfone I, Maetzler W (2017), [Diagnostics of clinical and prodromal idiopathic Parkinson's disease : New criteria]. Der Nervenarzt 88(4), 356-364, doi: 10.1007/s00115-017-0290-6.
Sartor J, Bettecken K, Bernhard FP, Hofmann M, Gladow T, Lindig T, Ciliz M, Ten Kate M, Geritz J, Heinzel S, Benedictus M, Scheltens P, Hobert MA, Maetzler W (2017), Corrigendum: White Matter Changes-Related Gait and Executive Function Deficits: Associations with Age and Parkinson's Disease. Frontiers in aging neuroscience 9, 342, doi: 10.3389/fnagi.2017.00342.
Theiss S, Maetzler W, Deuschle C, Lerche H, Koch H, Dihné M (2017), Dementia with Lewy bodies: cerebrospinal fluid suppresses neuronal network activity. Neuroreport 28(16), 1061-1065, doi: 10.1097/WNR.0000000000000890.
Liepelt-Scarfone I, Brändle B, Yilmaz R, Gauss K, Schaeffer E, Timmers M, Wurster I, Brockmann K, Maetzler W, Van Nueten L, Streffer JR, Berg D (2017), Progression of prodromal motor and non-motor symptoms in the premotor phase study - 2-year follow-up data. European journal of neurology 24(11), 1369-1374, doi: 10.1111/ene.13397.
Pham MH, Elshehabi M, Haertner L, Del Din S, Srulijes K, Heger T, Synofzik M, Hobert MA, Faber GS, Hansen C, Salkovic D, Ferreira JJ, Berg D, Sanchez-Ferro A, van Dieën JH, Becker C, Rochester L, Schmidt G, Maetzler W (2017), Validation of a Step Detection Algorithm during Straight Walking and Turning in Patients with Parkinson's Disease and Older Adults Using an Inertial Measurement Unit at the Lower Back. Frontiers in neurology 8, 457, doi: 10.3389/fneur.2017.00457.
Trezzi J-P, Galozzi S, Jaeger C, Barkovits K, Brockmann K, Maetzler W, Berg D, Marcus K, Betsou F, Hiller K, Mollenhauer B (2017), Distinct metabolomic signature in cerebrospinal fluid in early parkinson's disease. Movement disorders 32(10), 1401-1408, doi: 10.1002/mds.27132.
Heinzel D, Bernhard GP, Roeben B, Nussbaum D, Heger T, Martus P, Hobert MA, Maetzler W, Berg D (2017), Progression markers of motor deficits in Parkinson's disease: A biannual 4-year prospective study. Movement disorders 32(8), 1254-1256, doi: 10.1002/mds.27062.
Drey M, Hasmann SE, Krenovsky J-P, Hobert MA, Straub S, Elshehabi M, von Thaler A-K, Fallgatter AJ, Eschweiler GW, Suenkel U, Berg D, Maetzler W (2017), Associations between Early Markers of Parkinson's Disease and Sarcopenia. Frontiers in aging neuroscience 9, 53, doi: 10.3389/fnagi.2017.00053.
Wang Y, Balaji V, Kaniyappan S, Krüger L, Irsen S, Tepper K, Chandupatla R, Maetzler W, Schneider A, Mandelkow E, Mandelkow E-M (2017), The release and trans-synaptic transmission of Tau via exosomes. Molecular neurodegeneration 12(1), 5, doi: 10.1186/s13024-016-0143-y.
Heinzel S, Lerche S, Maetzler W, Berg D (2017), Global, Yet Incomplete Overview of Cohort Studies in Parkinson's disease. Journal of Parkinson's disease 7(3), 423-432, doi: 10.3233/JPD-171100.
van der Zee J, Gijselinck I, Van Mossevelde S, Perrone F, Dillen L, Heeman B, Bäumer V, Engelborghs S, De Bleecker J, Baets J, Gelpi E, Rojas-García R, Clarimón J, Lleó A, Diehl-Schmid J, Alexopoulos P, Perneczky R, Synofzik M, Just J, Schöls L, Graff C, Thonberg H, Borroni B, Padovani A, Jordanova A, Sarafov S, Tournev I, de Mendonça A, Miltenberger-Miltényi G, Simões do Couto F, Ramirez A, Jessen F, Heneka MT, Gómez-Tortosa E, Danek A, Cras P, Vandenberghe R, De Jonghe P, De Deyn PP, Sleegers K, Cruts M, Van Broeckhoven C, Goeman J, Nuytten D, Smets K, Robberecht W, Damme PV, Bleecker JD, Santens P, Dermaut B, Versijpt J, Michotte A, Ivanoiu A, Deryck O, Bergmans B, Delbeck J, Bruyland M, Willems C, Salmon E, Pastor P, Ortega-Cubero S, Benussi L, Ghidoni R, Binetti G, Hernández I, Boada M, Ruiz A, Sorbi S, Nacmias B, Bagnoli S, Sorbi S, Sanchez-Valle R, Llado A, Santana I, Rosário Almeida M, Frisoni GB, Maetzler W, Matej R, Fraidakis MJ, Kovacs GG, Fabrizi GM, Testi S (2017), TBK1 Mutation Spectrum in an Extended European Patient Cohort with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis. Human mutation 38(3), 297-309, doi: 10.1002/humu.23161.
Cerff B, Maetzler W, Sulzer P, Kampmeyer M, Prinzen J, Hobert MA, Blum D, van Lummel R, Del Din S, Gräber S, Berg D, Liepelt-Scarfone I (2017), Home-Based Physical Behavior in Late Stage Parkinson Disease Dementia: Differences between Cognitive Subtypes. Neurodegenerative diseases 17(4-5), 135-144, doi: 10.1159/000460251.
Wilke C, Gillardon R, Deuschle C, Hobert MA, Jansen IE, Metzger FG, Heutink P, Gasser T, Maetzler W, Blauwendraat C, Synofzik M (2017), Cerebrospinal Fluid Progranulin, but Not Serum Progranulin, Is Reduced in GRN-Negative Frontotemporal Dementia. Neurodegenerative diseases 17(2-3), 83-88, doi: 10.1159/000448896.
Brockmann K, Schulte C, Schneiderhan-Marra N, Apel A, Pont-Sunyer C, Vilas D, Ruiz-Martinez J, Langkamp M, Corvol J-C, Cormier F, Knorpp T, Joos TO, Bernard A, Gasser T, Marras C, Schüle B, Aasly JO, Foroud T, Marti-Masso JF, Brice A, Tolosa E, Berg D, Maetzler W (2017), Inflammatory profile discriminates clinical subtypes in LRRK2-associated Parkinson's disease. European journal of neurology 24(2), 427-e6, doi: 10.1111/ene.13223.
Micó-Amigo ME, Kingma I, Faber GS, Kunikoshi A, van Uem JMT, van Lummel RC, Maetzler W, van Dieën JH (2017), Is the Assessment of 5 Meters of Gait with a Single Body-Fixed-Sensor Enough to Recognize Idiopathic Parkinson's Disease-Associated Gait? Annals of biomedical engineering 45(5), 1266-1278, doi: 10.1007/s10439-017-1794-8.
Lerche S, Schulte C, Srulijes K, Pilotto A, Rattay TW, Hauser A-K, Stransky E, Deuschle C, Csoti I, Lachmann I, Zetterberg H, Liepelt-Scarfone I, Gasser T, Maetzler W, Berg D, Brockmann K (2017), Cognitive impairment in Glucocerebrosidase (GBA)-associated PD: Not primarily associated with cerebrospinal fluid Abeta and Tau profiles. Movement disorders 32(12), 1780-1783, doi: 10.1002/mds.27199.
Srulijes K, Brockmann K, Ogbamicael S, Hobert MA, Hauser A-K, Schulte C, Fritzen J, Schwenk M, Gasser T, Berg D, Maetzler W (2017), Dual-Task Performance in GBA Parkinson's Disease. Parkinson's disease 2017, 8582740, doi: 10.1155/2017/8582740.
Yilmaz R, Pilotto A, Roeben B, Preische O, Suenkel U, Heinzel S, Metzger FG, Laske C, Maetzler W, Berg D (2017), Erratum: Structural Ultrasound of the Medial Temporal Lobe in Alzheimer's Disease. Ultraschall in der Medizin 38(3), e16, doi: 10.1055/s-0035-1567111.
Kun-Rodrigues C, Ross OA, Orme T, Shepherd C, Parkkinen L, Darwent L, Hernandez D, Ansorge O, Clark LN, Honig LS, Marder K, Lemstra A, Scheltens P, van der Flier W, Louwersheimer E, Holstege H, Rogaeva E, St. George-Hyslop P, Londos E, Zetterberg H, Barber I, Braae A, Brown K, Morgan K, Maetzler W, Berg D, Troakes C, Al-Sarraj S, Lashley T, Holton J, Compta Y, Van Deerlin V, Trojanowski JQ, Serrano GE, Beach TG, Clarimon J, Lleó A, Morenas-Rodríguez E, Lesage S, Galasko D, Masliah E, Santana I, Diez M, Pastor P, Tienari PJ, Myllykangas L, Oinas M, Revesz T, Lees A, Boeve BF, Petersen RC, Ferman TJ, Escott-Price V, Graff-Radford N, Cairns NJ, Morris JC, Stone DJ, Pickering-Brown S, Mann D, Dickson DW, Halliday GM, Singleton A, Guerreiro R, Bras J (2017), Analysis of C9orf72 repeat expansions in a large international cohort of dementia with Lewy bodies. Neurobiology of Aging 49, 214.e13-214.e15, url, doi: 10.1016/j.neurobiolaging.2016.08.023.
Robak LA, Jansen IE, Rooij J van, Uitterlinden AG, Kraaij R, Jankovic J, Heutink P, Shulman JM, Nalls MA, Plagnol V, Hernandez DG, Sharma M, Sheerin UM, Saad M, Simón-Sánchez J, Schulte C, Lesage S, Sveinbjörnsdóttir S, Arepalli S, Barker R, Ben Y, Berendse HW, Berg D, Bhatia K, de Bie RMA, Biffi A, Bloem B, Bochdanovits Z, Bonin M, Bras JM, Brockmann K, Brooks J, Burn DJ, Majounie E, Charlesworth G, Lungu C, Chen H, Chinnery PF, Chong S, Clarke CE, Cookson MR, Cooper JM, Corvol JC, Counsell C, Damier P, Dartigues JF, Deloukas P, Deuschl G, Dexter DT, van Dijk KD, Dillman A, Durif F, Dürr A, Edkins S, Evans JR, Foltynie T, Dong J, Gardner M, Gibbs JR, Goate A, Gray E, Guerreiro R, Harris C, van Hilten JJ, Hofman A, Hollenbeck A, Holton J, Hu M, Huang X, Wurster I, Mätzler W, Hudson G, Hunt SE, Huttenlocher J, Illig T, Jónsson PV, Lambert JC, Langford C, Lees A, Lichtner P, Limousin P, Lopez G, Lorenz D, Lungu C, McNeill A, Moorby C, Moore M, Morris HR, Morrison KE, Escott-Price V, Mudanohwo E, O’sullivan SS, Pearson J, Perlmutter JS, Pétursson H, Pollak P, Post B, Potter S, Ravina B, Revesz T, Riess O, Rivadeneira F, Rizzu P, Ryten M, Sawcer S, Schapira A, Scheffer H, Shaw K, Shoulson I, Shulman J, Sidransky E, Smith C, Spencer CCA, Stefánsson H, Bettella F, Stockton JD, Strange A, Talbot K, Tanner CM, Tashakkori-Ghanbaria A, Tison F, Trabzuni D, Traynor BJ, Uitterlinden AG, Velseboer D, Vidailhet M, Walker R, Warrenburg B van de, Wickremaratchi M, Williams N, Williams-Gray CH, Winder-Rhodes S, Stefánsson K, Martinez M, Wood NW, Hardy J, Heutink P, Brice A, Gasser T, Singleton AB (2017), Excessive burden of lysosomal storage disorder gene variants in Parkinson's disease. Brain 140(12), 3191-3203, doi: 10.1093/brain/awx285.
Jansen IE, Ye H, Heetveld S, Lechler MC, Michels H, Seinstra RI, Lubbe SJ, Drouet V, Lesage S, Majounie E, Gibbs JR, Nalls MA, Ryten M, Botia JA, Vandrovcova J, Simon-Sanchez J, Castillo-Lizardo M, Rizzu P, Blauwendraat C, Chouhan AK, Li Y, Yogi P, Amin N, van Duijn CM, Morris HR, Brice A, Singleton AB, David DC, Nollen EA, Jain S, Shulman JM, Heutink P, Hernandez DG, Arepalli S, Brooks J, Price R, Nicolas A, Chong S, Cookson MR, Dillman A, Moore M, Traynor BJ, Singleton AB, Plagnol V, Nicholas W Wood, Sheerin UM, Jose M Bras, Charlesworth G, Gardner M, Guerreiro R, Trabzuni D, Hardy J, Sharma M, Saad M, Javier Simón-Sánchez, Schulte C, Corvol JC, Dürr A, Vidailhet M, Sveinbjörnsdóttir S, Barker R, Caroline H Williams-Gray, Ben-Shlomo Y, Berendse HW, van Dijk KD, Berg D, Brockmann K, Wurster I, Mätzler W, Gasser T, Martinez M, de Bie RMA, Biffi A, Velseboer D, Bloem B, Post B, Wickremaratchi M, van de Warrenburg B, Bochdanovits Z, Bonin M, Pétursson H, Riess O, Burn DJ, Lubbe S, Cooper JM, McNeill A, Schapira A, Lungu C, Chen H, Dong J, Chinnery PF, Hudson G, Clarke CE, Moorby C, Counsell C, Damier P, Dartigues JF, Deloukas P, Gray E, Edkins S, Hunt SE, Potter S, Tashakkori-Ghanbaria A, Deuschl G, Lorenz D, Dexter DT, Durif F, Evans JR, Langford C, Foltynie T, Goate A, Harris C, van Hilten JJ, Hofman A, Hollenbeck A, Holton J, Hu M, Huang X, Illig T, Jónsson PV, Lambert JC, O'Sullivan SS, Revesz T, Shaw K, Lees A, Lichtner P, Limousin P, Lopez G, Escott-Price V, Pearson J, Williams N, Mudanohwo E, Perlmutter JS, Pollak P, Rivadeneira F, Uitterlinden AG, Sawcer S, Scheffer H, Shoulson I, Shulman J, Smith C, Walker R, Spencer CCA, Strange A, Stefánsson H, Bettella F, Stefánsson K, Stockton JD, Talbot K, Tanner CM, Tison F, Winder-Rhodes S, Bhatia K (2017), Discovery and functional prioritization of Parkinson's disease candidate genes from large-scale whole exome sequencing. Genome biology 18(1), doi: 10.1186/S13059-017-1147-9.
van Uem JMT, Marinus J, Canning C, van Lummel R, Dodel R, Liepelt-Scarfone I, Berg D, Morris ME, Maetzler W (2016), Health-Related Quality of Life in patients with Parkinson's disease A systematic review based on the ICF model. Neuroscience and biobehavioral reviews 61, 26-34, doi: 10.1016/j.neubiorev.2015.11.014.
Keller A, Backes C, Haas J, Leidinger P, Maetzler W, Deuschle C, Berg D, Ruschil C, Galata V, Ruprecht K, Staehler C, Wuerstle M, Sickert D, Gogol M, Meder B, Meese E (2016), Validating Alzheimer's disease micro RNAs using next-generation sequencing. Alzheimer's & dementia 12(5), 565-576, doi: 10.1016/j.jalz.2015.12.012.
Lerche S, Brockmann K, Pilotto A, Wurster I, Suenkel U, Hobert MA, von Thaler A-K, Schulte C, Stoops E, Vanderstichele H, Herbst V, Brix B, Eschweiler GW, Metzger FG, Maetzler W, Berg D (2016), Prospective longitudinal course of cognition in older subjects with mild parkinsonian signs. Alzheimers research & therapy 8, 42, doi: 10.1186/s13195-016-0209-7.
Ramsperger R, Meckler S, Heger T, van Uem J, Hucker S, Braatz U, Graessner H, Berg D, Manoli Y, Serrano JA, Ferreira JJ, Hobert MA, Maetzler W, Team SENSE-PARKS (2016), Continuous leg dyskinesia assessment in Parkinson's disease -clinical validity and ecological effect. Parkinsonism & related disorders 26, 41-46, doi: 10.1016/j.parkreldis.2016.02.007.
Sanchez-Ferro A, Elshehabi M, Godinho C, Salkovic D, Hobert MA, Domingos J, van Uem JMT, Ferreira JJ, Maetzler W (2016), New methods for the assessment of Parkinson's disease (2005 to 2015): A systematic review. Movement Disorders 31(9), 1283-1292, doi: 10.1002/mds.26723.
van Uem JMT, Walgaard S, Ainsworth E, Hasmann SE, Heger T, Nussbaum S, Hobert MA, Mico-Amigo EM, Van Lummel RC, Berg D, Maetzler W (2016), Quantitative Timed-Up-and-Go Parameters in Relation to Cognitive Parameters and Health-Related Quality of Life in Mild-to-Moderate Parkinson's Disease. PloS one 11(4), e0151997, doi: 10.1371/journal.pone.0151997.
Santoro M, Maetzler W, Stathakos P, Martin HL, Hobert MA, Rattay TW, Gasser T, Forrester JV, Berg D, Tracey KJ, Riedel G, Teismann P (2016), In-vivo evidence that high mobility group box 1 exerts deleterious effects in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model and Parkinson's disease which can be attenuated by glycyrrhizin. Neurobiology of disease 91, 59-68, doi: 10.1016/j.nbd.2016.02.018.
Bacioglu M, Maia LF, Preische O, Schelle J, Apel A, Kaeser SA, Schweighauser M, Eninger T, Lambert M, Pilotto A, Shimshek DR, Neumann Z, Kahle PJ, Staufenbiel M, Neumann M, Maetzler W, Kuhle J, Jucker M (2016), Neurofilament Light Chain in Blood and CSF as Marker of Disease Progression in Mouse Models and in Neurodegenerative Diseases (vol 91, pg 56, 2016). Neuron 91(2), 494-496, doi: 10.1016/j.neuron.2016.07.007.
Roeben B, Maetzler W, Vanmechelen E, Schulte C, Heinzel S, Stellos K, Godau J, Huber H, Brockmann K, Wurster I, Gaenslen A, Gruener E, Niebler R, Eschweiler GW, Berg D, Team TRENDS (2016), Association of Plasma A beta(40) Peptides, But Not A beta(42), with Coronary Artery Disease and Diabetes Mellitus. Journal of Alzheimer's disease 52(1), 161-169, doi: 10.3233/JAD-150575.
Klenk J, Srulijes K, Schatton C, Schwickert L, Maetzler W, Becker C, Synofzik M (2016), Ambulatory Activity Components Deteriorate Differently across Neurodegenerative Diseases: A Cross-Sectional Sensor-Based Study. Neurodegenerative diseases 16(5-6), 317-323, doi: 10.1159/000444802.
Goldeck D, Maetzler W, Berg D, Oettinger L, Pawelec G (2016), Altered dendritic cell subset distribution in patients with Parkinson's disease: Impact of CMV serostatus. Journal of neuroimmunology 290, 60-65, doi: 10.1016/j.jneuroim.2015.11.008.
Pilotto A, Schulte C, Hauser AK, Biskup S, Munz M, Brockmann K, Schaeffer E, Synofzik M, Maetzler W, Suenkel U, Srulijes K, Gasser T, Berg D (2016), GBA-associated parkinsonism and dementia: beyond -synucleinopathies? European journal of neurology 23(3), 520-526, doi: 10.1111/ene.12894.
van Uem JMT, Maier KS, Hucker S, Scheck O, Hobert MA, Santos AT, Fagerbakke O, Larsen F, Ferreira JJ, Maetzler W (2016), Twelve-week sensor assessment in Parkinson's disease: Impact on quality of life. Movement disorders 31(9), 1337-1338, doi: 10.1002/mds.26676.
van Lummel RC, Walgaard S, Hobert MA, Maetzler W, van Dieen JH, Galindo-Garre F, Terwee CB (2016), Intra-Rater, Inter-Rater and Test-Retest Reliability of an Instrumented Timed Up and Go (iTUG) Test in Patients with Parkinson's Disease. PloS one 11(3), doi: 10.1371/journal.pone.0151881.
Blauwendraat C, Wilke C, Jansen IE, Schulte C, Simon-Sanchez J, Metzger FG, Bender B, Gasser T, Maetzler W, Rizzu P, Heutink P, Synofzik M (2016), Pilot whole-exome sequencing of a German early-onset Alzheimer's disease cohort reveals a substantial frequency of PSEN2 variants. Neurobiology of aging 37, 208.e11-208.e17, doi: 10.1016/j.neurobiolaging.2015.09.016.
Heinzel S, Roeben B, Ben-Shlomo Y, Lerche S, Alves G, Barone P, Behnke S, Berendse HW, Bloem BR, Burn F, Dodel R, Grosset DG, Hu M, Kasten M, Krueger R, Moccia M, Mollenhauer B, Oertel W, Suenkel U, Walter U, Wirdefeldt K, Liepelt-Scarfone I, Maetzler W, Berg D (2016), Prodromal Markers in Parkinson's Disease: Limitations in Longitudinal Studies and Lessons Learned. Frontiers in aging neuroscience 8, 147, doi: 10.3389/fnagi.2016.00147.
Lerche S, Heinzel S, Alves GW, Barone P, Behnke S, Ben-Shlomo Y, Berendse H, Bloem BR, Burn D, Dodel R, Grosset DG, Hipp G, Hu MT, Kasten M, Kruger R, Liepelt-Scarfone I, Maetzler W, Moccia M, Mollenhauer B, Oertel W, Roeben B, Walter U, Wirdefeldt K, Berg D (2016), Aiming for Study Comparability in Parkinson's Disease: Proposal for a Modular Set of Biomarker Assessments to be Used in Longitudinal Studies. Frontiers in aging neuroscience 8, 121, doi: 10.3389/fnagi.2016.00121.
Yilmaz R, Behnke S, Liepelt-Scarfone I, Roeben B, Pausch C, Runkel A, Heinzel S, Niebler R, Suenkel U, Eschweiler GW, Maetzler W, Berg D (2016), Substantia nigra hyperechogenicity is related to decline in verbal memory in healthy elderly adults. European journal of neurology 23(5), 973-978, doi: 10.1111/ene.12974.
Elshehabi M, Maier KS, Hasmann SE, Nussbaum S, Herbst H, Heger T, Berg D, Hobert MA, Maetzler W (2016), Limited Effect of Dopaminergic Medication on Straight Walking and Turning in Early-to-Moderate Parkinson's Disease during Single and Dual Tasking. Frontiers in aging neuroscience 8, 4, doi: 10.3389/fnagi.2016.00004.
Schlenstedt C, Maetzler W (2016), Gait- and Balance Disturbance of common Age-associated neurologic Diseases. Deutsche medizinische Wochenschrift 141(20), 1441-1444, doi: 10.1055/s-0042-112082.
Sanchez-Ferro A, Maetzler W (2016), Advances in sensor and wearable technologies for Parkinson's disease. Movement disorders 31(9), 1257, doi: 10.1002/mds.26746.
Lawton M, Kasten M, May MT, Mollenhauer B, Schaumburg M, Liepelt-Scarfone I, Maetzler W, Vollstedt E-J, Hu MTM, Berg D, Ben-Shlomo Y (2016), Validation of conversion between mini-mental state examination and montreal cognitive assessment. Movement disorders 31(4), 593-596, doi: 10.1002/mds.26498.
van Uem JMT, Isaacs T, Lewin A, Bresolin E, Salkovic D, Espay AJ, Matthews H, Maetzler W (2016), A Viewpoint on Wearable Technology-Enabled Measurement of Wellbeing and Health-Related Quality of Life in Parkinson's Disease. Journal of Parkinson's disease 6(2), 279-287, doi: 10.3233/JPD-150740.
Maetzler W, Rattay TW, Hobert MA, Synofzik M, Bader A, Berg D, Schaeffer E, Rommel N, Devos D, Bloem BR, Bender B (2016), Freezing of Swallowing. Movement disorders clinical practice 3(5), 490-493, doi: 10.1002/mdc3.12314.
Espay AJ, Bonato P, Nahab FB, Maetzler W, Dean JM, Klucken J, Eskofier BM, Merola A, Horak F, Lang AE, Reilmann R, Giuffrida J, Nieuwboer A, Horne M, Little MA, Litvan I, Simuni T, Dorsey ER, Burack MA, Kubota K, Kamondi A, Godinho C, Daneault J-F, Mitsi G, Krinke L, Hausdorff JM, Bloem BR, Papapetropoulos S, Force MDST (2016), Technology in Parkinson's disease: Challenges and opportunities. Movement disorders 31(9), 1272-1282, doi: 10.1002/mds.26642.
Bernhard FP, Heinzel S, Binder G, Weber K, Apel A, Roeben B, Deuschle C, Maechtel M, Heger T, Nussbaum S, Gasser T, Maetzler W, Berg D (2016), Insulin-Like Growth Factor 1 (IGF-1) in Parkinson's Disease: Potential as Trait-, Progression- and Prediction Marker and Confounding Factors. PloS one 11(3), e0150552, doi: 10.1371/journal.pone.0150552.
Heinzel S, Maechtel M, Hasmann SE, Hobert MA, Heger T, Berg D, Maetzler W (2016), Motor dual-tasking deficits predict falls in Parkinson's disease: A prospective study. Parkinsonism & related disorders 26, 73-77, doi: 10.1016/j.parkreldis.2016.03.007.
Wilke C, Gillardon R, Deuschle C, Dubois E, Hobert MA, Mueller vom Hagen J, Krueger S, Biskup S, Blauwendraat C, Hruscha M, Kaeser SA, Heutink P, Maetzler W, Synofzik M (2016), Serum Levels of Progranulin Do Not Reflect Cerebrospinal Fluid Levels in Neurodegenerative Disease. Current Alzheimer research 13(6), 654-662, doi: 10.2174/1567205013666160314151247.
Maetzler W, Krüger R, Müller T, Oertel W, Urban P, Warnecke T, Klucken J (2016), [Wearable Technique for the Assessment of Parkinson Symptoms: What's the Future?]. Fortschritte der Neurologie-Psychiatrie 84 Suppl 1, S48-51, doi: 10.1055/s-0042-102786.
Maetzler W, Klucken J, Horne M (2016), A clinical view on the development of technology-based tools in managing Parkinson's disease. Movement disorders 31(9), 1263-1271, doi: 10.1002/mds.26673.
Maetzler W, Deleersnijder W, Hanssens V, Bernard A, Brockmann K, Marquetand J, Wurster I, Rattay TW, Roncoroni L, Schaeffer E, Lerche S, Apel A, Deuschle C, Berg D (2016), GDF15/MIC1 and MMP9 Cerebrospinal Fluid Levels in Parkinson's Disease and Lewy Body Dementia. PloS one 11(3), e0149349, doi: 10.1371/journal.pone.0149349.
Godinho C, Domingos J, Cunha G, Santos AT, Fernandes RM, Abreu D, Gonçalves N, Matthews H, Isaacs T, Duffen J, Al-Jawad A, Larsen F, Serrano A, Weber P, Thoms A, Sollinger S, Graessner H, Maetzler W, Ferreira JJ (2016), A systematic review of the characteristics and validity of monitoring technologies to assess Parkinson’s disease. Journal of neuroengineering and rehabilitation 13(1), 24, doi: 10.1186/s12984-016-0136-7.
Wilke C, Preische O, Deuschle C, Roeben B, Apel A, Barro C, Maia L, Maetzler W, Kuhle J, Synofzik M (2016), Neurofilament light chain in FTD is elevated not only in cerebrospinal fluid, but also in serum. Journal of neurology, neurosurgery, and psychiatry 87(11), 1270-1272, doi: 10.1136/jnnp-2015-312972.
Godinho C, Domingos J, Cunha G, Santos AT, Fernandes RM, Abreu D, Gonçalves N, Matthews H, Isaacs T, Duffen J, Al-Jawad A, Larsen F, Serrano A, Weber P, Thoms A, Sollinger S, Graessner H, Maetzler W, Ferreira JJ (2016), Erratum to: A systematic review of the characteristics and validity of monitoring technologies to assess Parkinson's disease. Journal of neuroengineering and rehabilitation 13(1), 71, doi: 10.1186/s12984-016-0181-2.
Metzger FG, Hobert MA, Ehlis A-C, Hasmann SE, Hahn T, Eschweiler GW, Berg D, Fallgatter AJ, Maetzler W, TREND Study team (2016), Dual Tasking for the Differentiation between Depression and Mild Cognitive Impairment. Frontiers in aging neuroscience 8, 235, doi: 10.3389/fnagi.2016.00235.
Klenk J, Schwickert L, Palmerini L, Mellone S, Bourke A, Ihlen EAF, Kerse N, Hauer K, Pijnappels M, Synofzik M, Srulijes K, Maetzler W, Helbostad JL, Zijlstra W, Aminian K, Todd C, Chiari L, Becker C, FARSEEING Consortium (2016), The FARSEEING real-world fall repository: a large-scale collaborative database to collect and share sensor signals from real-world falls. European review of aging and physical activity 13(1), 8, doi: 10.1186/s11556-016-0168-9.
Yilmaz R, Gräber S, Roeben B, Suenkel U, von Thaler A-K, Heinzel S, Metzger FG, Eschweiler GW, Maetzler W, Berg D, Liepelt-Scarfone I (2016), Cognitive Performance Patterns in Healthy Individuals with Substantia Nigra Hyperechogenicity and Early Parkinson's Disease. Frontiers in aging neuroscience 8, 271, doi: 10.3389/fnagi.2016.00271.
Brockmann K, Apel A, Schulte C, Schneiderhan-Marra N, Pont-Sunyer C, Vilas D, Ruiz-Martinez J, Langkamp M, Corvol J-C, Cormier F, Knorpp T, Joos TO, Gasser T, Schüle B, Aasly JO, Foroud T, Marti-Masso JF, Brice A, Tolosa E, Marras C, Berg D, Maetzler W (2016), Inflammatory profile in LRRK2-associated prodromal and clinical PD. Journal of neuroinflammation 13(1), 122, doi: 10.1186/s12974-016-0588-5.
Bacioglu M, Maia LF, Preische O, Schelle J, Apel A, Kaeser SA, Schweighauser M, Eninger T, Lambert M, Pilotto A, Shimshek DR, Neumann U, Kahle PJ, Staufenbiel M, Neumann M, Maetzler W, Kuhle J, Jucker M (2016), Neurofilament Light Chain in Blood and CSF as Marker of Disease Progression in Mouse Models and in Neurodegenerative Diseases. Neuron 91(1), 56-66, doi: 10.1016/j.neuron.2016.05.018.
Guerreiro R, Escott-Price V, Darwent L, Parkkinen L, Ansorge O, Hernandez DG, Nalls MA, Clark L, Honig L, Marder K, van der Flier W, Holstege H, Louwersheimer E, Lemstra A, Scheltens P, Rogaeva E, St George-Hyslop P, Londos E, Zetterberg H, Ortega-Cubero S, Pastor P, Ferman TJ, Graff-Radford NR, Ross OA, Barber I, Braae A, Brown K, Morgan K, Maetzler W, Berg D, Troakes C, Al-Sarraj S, Lashley T, Compta Y, Revesz T, Lees A, Cairns NJ, Halliday GM, Mann D, Pickering-Brown S, Powell J, Lunnon K, Lupton MK, (IPDGC) IP's DGC, Dickson D, Hardy J, Singleton A, Bras J (2016), Genome-wide analysis of genetic correlation in dementia with Lewy bodies, Parkinson's and Alzheimer's diseases. Neurobiology of aging 38, 214.e7-214.e10, doi: 10.1016/j.neurobiolaging.2015.10.028.
Lesage S, Drouet V, Majounie E, Deramecourt V, Jacoupy M, Nicolas A, Cormier-Dequaire F, Hassoun SM, Pujol C, Ciura S, Erpapazoglou Z, Usenko T, Maurage C-A, Sahbatou M, Liebau S, Ding J, Bilgic B, Emre M, Erginel-Unaltuna N, Guven G, Tison F, Tranchant C, Vidailhet M, Corvol J-C, Krack P, Leutenegger A-L, Nalls MA, Hernandez DG, Heutink P, Gibbs JR, Hardy J, Wood NW, Gasser T, Durr A, Deleuze J-F, Tazir M, Destée A, Lohmann E, Kabashi E, Singleton AB, Corti O, Brice A, (PDG) FP's DGS, (IPDGC) IP's DGC (2016), Loss of VPS13C Function in Autosomal-Recessive Parkinsonism Causes Mitochondrial Dysfunction and Increases PINK1/Parkin-Dependent Mitophagy. The American journal of human genetics 98(3), 500-513, doi: 10.1016/j.ajhg.2016.01.014.
Stamelou M, Schöpe J, Wagenpfeil S, Del Ser T, Bang J, Lobach IY, Luong P, Respondek G, Oertel WH, Boxer AL, Höglinger JU, AL-108-231 Investigators, Tauros Investigators and MDS-EPSPSG (2016), Power calculations and placebo effect for future clinical trials in progressive supranuclear palsy. Movement disorders 31(5), 742-7, doi: 10.1002/mds.26580.
Synofzik M, Maetzler W (2015), [Successful aging: what can neurology and geriatrics contribute?]. Der Nervenarzt 86(4), 475-80, doi: 10.1007/s00115-014-4194-4.
Maetzler W, Ellerbrock M, Heger T, Sass C, Berg D, Reilmann R (2015), Digitomotography in Parkinson's disease: a cross-sectional and longitudinal study. PloS one 10(4), e0123914, doi: 10.1371/journal.pone.0123914.
Maetzler W, Drey M, Jacobs AH (2015), [Sarcopenia and frailty in neurology]. Der Nervenarzt 86(4), 420-30, doi: 10.1007/s00115-014-4181-9.
Herfurth M, Godau J, Kattner B, Rombach S, Grau S, Maetzler W, Berg D (2015), Gait velocity and step length at baseline predict outcome of Nordic walking training in patients with Parkinson's disease. Parkinsonism & related disorders 21(4), 413-6, doi: 10.1016/j.parkreldis.2015.01.016.
Maetzler W, Karam M, Berger MF, Heger T, Maetzler C, Ruediger H, Bronzova J, Pita Lobo P, Ferreira JJ, Ziemssen T, Berg D (2015), Time- and frequency-domain parameters of heart rate variability and sympathetic skin response in Parkinson's disease. Journal of neural transmission 122(3), 419-25, doi: 10.1007/s00702-014-1276-1.
Brockmann K, Srulijes K, Pflederer S, Hauser A-K, Schulte C, Maetzler W, Gasser T, Berg D (2015), GBA-associated Parkinson's disease: reduced survival and more rapid progression in a prospective longitudinal study. Movement disorders 30(3), 407-11, doi: 10.1002/mds.26071.
Wilke C, Deuschle C, Rattay TW, Maetzler W, Synofzik M (2015), Total tau is increased, but phosphorylated tau not decreased, in cerebrospinal fluid in amyotrophic lateral sclerosis. Neurobiology of aging 36(2), 1072-4, doi: 10.1016/j.neurobiolaging.2014.10.019.
Lerche S, Brockmann K, Wurster I, Gaenslen A, Roeben B, Holz D, Eschweiler GW, Maetzler W, Berg D (2015), Reasons for mild parkinsonian signs - which constellation may indicate neurodegeneration? Parkinsonism & related disorders 21(2), 126-30, doi: 10.1016/j.parkreldis.2014.11.018.
Serrano JA, Larsen F, Isaacs T, Matthews H, Duffen J, Riggare S, Capitanio F, Ferreira JJ, Domingos J, Maetzler W, Graessner H, SENSE-PARK Consortium (2015), Participatory design in Parkinson's research with focus on the symptomatic domains to be measured. Journal of Parkinson's disease 5(1), 187-96, doi: 10.3233/JPD-140472.
Ferreira JJ, Santos AT, Domingos J, Matthews H, Isaacs T, Duffen J, Al-Jawad A, Larsen F, Artur Serrano J, Weber P, Thoms A, Sollinger S, Graessner H, Maetzler W (2015), Clinical Parameters and Tools for Home-Based Assessment of Parkinson's Disease: Results from a Delphi study. Journal of Parkinson's disease 5(2), 281-90, doi: 10.3233/JPD-140493.
Lerche S, Liepelt-Scarfone I, Alves G, Barone P, Behnke S, Ben-Shlomo Y, Berendse H, Burn D, Dodel R, Grosset D, Heinzel S, Hu M, Kasten M, Krüger R, Maetzler W, Moccia M, Mollenhauer B, Oertel W, Roeben B, Sünkel U, Walter U, Wirdefeldt K, Berg D (2015), Methods in Neuroepidemiology Characterization of European Longitudinal Cohort Studies in Parkinson's Disease--Report of the JPND Working Group BioLoC-PD. Neuroepidemiology 45(4), 282-97, doi: 10.1159/000439221.
Louter M, Maetzler W, Prinzen J, van Lummel RC, Hobert M, Arends JBAM, Bloem BR, Streffer J, Berg D, Overeem S, Liepelt-Scarfone I (2015), Accelerometer-based quantitative analysis of axial nocturnal movements differentiates patients with Parkinson's disease, but not high-risk individuals, from controls. Journal of neurology, neurosurgery, and psychiatry 86(1), 32-7, doi: 10.1136/jnnp-2013-306851.
Brockmann K, Schulte C, Deuschle C, Hauser A-K, Heger T, Gasser T, Maetzler W, Berg D (2015), Neurodegenerative CSF markers in genetic and sporadic PD: Classification and prediction in a longitudinal study. Parkinsonism & related disorders 21(12), 1427-34, doi: 10.1016/j.parkreldis.2015.10.008.
Ewers M, Mattsson N, Minthon L, Molinuevo JL, Antonell A, Popp J, Jessen F, Herukka S-K, Soininen H, Maetzler W, Leyhe T, Bürger K, Taniguchi M, Urakami K, Lista S, Dubois B, Blennow K, Hampel H (2015), CSF biomarkers for the differential diagnosis of Alzheimer's disease: A large-scale international multicenter study. Alzheimer's & dementia 11(11), 1306-15, doi: 10.1016/j.jalz.2014.12.006.
Heinzel S, Metzger FG, Ehlis A-C, Korell R, Alboji A, Haeussinger FB, Wurster I, Brockmann K, Suenkel U, Eschweiler GW, Maetzler W, Berg D, Fallgatter AJ (2015), Age and Vascular Burden Determinants of Cortical Hemodynamics Underlying Verbal Fluency. PloS one 10(9), e0138863, doi: 10.1371/journal.pone.0138863.
Srulijes K, Mack DJ, Klenk J, Schwickert L, Ihlen EAF, Schwenk M, Lindemann U, Meyer M, Srijana KC, Hobert MA, Brockmann K, Wurster I, Pomper JK, Synofzik M, Schneider E, Ilg U, Berg D, Maetzler W, Becker C (2015), Association between vestibulo-ocular reflex suppression, balance, gait, and fall risk in ageing and neurodegenerative disease: protocol of a one-year prospective follow-up study. BMC neurology 15(1), 192, doi: 10.1186/s12883-015-0447-5.
Schaeffer E, Maetzler W, Liepelt-Scarfone I, Sass C, Reilmann R, Berg D (2015), Quantitative motor assessment of dyskinesias in Parkinson's disease. Journal of neural transmission 122(9), 1271-8, doi: 10.1007/s00702-015-1383-7.
Reijs BLR, Teunissen CE, Goncharenko N, Betsou F, Blennow K, Baldeiras I, Brosseron F, Cavedo E, Fladby T, Froelich L, Gabryelewicz T, Gurvit H, Kapaki E, Koson P, Kulic L, Lehmann S, Lewczuk P, Lleó A, Maetzler W, de Mendonça A, Miller A-M, Molinuevo JL, Mollenhauer B, Parnetti L, Rot U, Schneider A, Simonsen AH, Tagliavini F, Tsolaki M, Verbeek MM, Verhey FRJ, Zboch M, Winblad B, Scheltens P, Zetterberg H, Visser PJ (2015), The Central Biobank and Virtual Biobank of BIOMARKAPD: A Resource for Studies on Neurodegenerative Diseases. Frontiers in neurology 6, 216, doi: 10.3389/fneur.2015.00216.
Maetzler W, Rochester L (2015), Body-worn sensors--the brave new world of clinical measurement? Movement disorders 30(9), 1203-5, doi: 10.1002/mds.26317.
Hagen K, Ehlis A-C, Haeussinger FB, Beeretz S, Kromer GV, Heinzel S, Maetzler W, Eschweiler GW, Berg D, Fallgatter AJ, Metzger FG, TREND Study Consortium (2015), The relation of SMI and the VSEP in a risk sample for neurodegenerative disorders. Journal of neural transmission 122(8), 1167-74, doi: 10.1007/s00702-014-1351-7.
Sartorius T, Peter A, Heni M, Maetzler W, Fritsche A, Häring H-U, Hennige AM (2015), The brain response to peripheral insulin declines with age: a contribution of the blood-brain barrier? PloS one 10(5), e0126804, doi: 10.1371/journal.pone.0126804.
Laske C, Stellos K, Kempter I, Stransky E, Maetzler W, Fleming I, Randriamboavonjy V (2015), Increased cerebrospinal fluid calpain activity and microparticle levels in Alzheimer's disease. Alzheimer's & dementia 11(5), 465-74, doi: 10.1016/j.jalz.2014.06.003.
Ferreira JJ, Godinho C, Santos AT, Domingos J, Abreu D, Lobo R, Gonçalves N, Barra M, Larsen F, Fagerbakke Ø, Akeren I, Wangen H, Serrano JA, Weber P, Thoms A, Meckler S, Sollinger S, van Uem J, Hobert MA, Maier KS, Matthew H, Isaacs T, Duffen J, Graessner H, Maetzler W (2015), Quantitative home-based assessment of Parkinson's symptoms: the SENSE-PARK feasibility and usability study. BMC neurology 15(1), 89, doi: 10.1186/s12883-015-0343-z.
Nalls MA, Bras J, Hernandez DG, Keller MF, Majounie E, Renton AE, Saad M, Jansen I, Guerreiro R, Lubbe S, Plagnol V, Gibbs JR, Schulte C, Pankratz N, Sutherland M, Bertram L, Lill CM, DeStefano AL, Faroud T, Eriksson N, Tung JY, Edsall C, Nichols N, Brooks J, Arepalli S, Pliner H, Letson C, Heutink P, Martinez M, Gasser T, Traynor BJ, Wood N, Hardy J, Singleton AB, International Parkinson's Disease Genomics Consortium (IPDGC), Parkinson's Disease meta-analysis consortium (2015), NeuroX, a fast and efficient genotyping platform for investigation of neurodegenerative diseases. Neurobiology of aging 36(3), 1605.e7-1605.e12, doi: 10.1016/j.neurobiolaging.2014.07.028.
Cornelis MC, Byrne EM, Esko T, Nalls MA, Ganna A, Paynter N, Monda KL, Amin N, Fischer K, Renstrom F, Ngwa JS, Huikari V, Cavadino A, Nolte IM, Teumer A, Yu K, Marques-Vidal P, Rawal R, Manichaikul A, Wojczynski MK, Vink JM, Zhao JH, Burlutsky G, Lahti J, Mikkilä V, Lemaitre RN, Eriksson J, Musani SK, Tanaka T, Geller F, Luan J, Hui J, Mägi R, Dimitriou M, Garcia ME, Ho W-K, Wright MJ, Rose LM, Magnusson PKE, Pedersen NL, Couper D, Oostra BA, Hofman A, Ikram MA, Tiemeier HW, Uitterlinden AG, van Rooij FJA, Barroso I, Johansson I, Xue L, Kaakinen M, Milani L, Power C, Snieder H, Stolk RP, Baumeister SE, Biffar R, Gu F, Bastardot F, Kutalik Z, Jacobs DR, Forouhi NG, Mihailov E, Lind L, Lindgren C, Michaëlsson K, Morris A, Jensen M, Khaw K-T, Luben RN, Wang JJ, Männistö S, Perälä M-M, Kähönen M, Lehtimäki T, Viikari J, Mozaffarian D, Mukamal K, Psaty BM, Döring A, Heath AC, Montgomery GW, Dahmen N, Carithers T, Tucker KL, Ferrucci L, Boyd HA, Melbye M, Treur JL, Mellström D, Hottenga JJ, Prokopenko I, Tönjes A, Deloukas P, Kanoni S, Lorentzon M, Houston DK, Liu Y, Danesh J, Rasheed A, Mason MA, Zonderman AB, Franke L, Kristal BS, Karjalainen J, Reed DR, Westra H-J, Evans MK, Saleheen D, Harris TB, Dedoussis G, Curhan G, Stumvoll M, Beilby J, Pasquale LR, Feenstra B, Bandinelli S, Ordovas JM, Chan AT, Peters U, Ohlsson C, Gieger C, Martin NG, Waldenberger M, Siscovick DS, Raitakari O, Eriksson JG, Mitchell P, Hunter DJ, Kraft P, Rimm EB, Boomsma DI, Borecki IB, Loos RJF, Wareham NJ, Vollenweider P, Caporaso N, Grabe HJ, Neuhouser ML, Wolffenbuttel BHR, Hu FB, Hyppönen E, Järvelin M-R, Cupples LA, Franks PW, Ridker PM, van Duijn CM, Heiss G, Metspalu A, North KE, Ingelsson E, Nettleton JA, van Dam RM, Chasman DI, Ingelsson E, Nettleton JA, van Dam RM, Chasman DI (2015), Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption. Molecular psychiatry 20(5), 647-656, doi: 10.1038/mp.2014.107.
Hasmann SE, Berg D, Hobert MA, Weiss D, Lindemann U, Streffer J, Liepelt-Scarfone I, Maetzler W (2014), Instrumented functional reach test differentiates individuals at high risk for Parkinson's disease from controls. Frontiers in aging neuroscience 6, 286, doi: 10.3389/fnagi.2014.00286.
Maetzler W, Pilotto A, Apel A, Deuschle C, Kuebart G, Heinzel S, Liepelt-Scarfone I, Schulte C, Reusch D, Schleicher E, Rothfuss O, Schneider A, Dodel R, Gasser T, Berg D (2014), In vivo markers of Parkinson's disease and dementia with Lewy bodies: current value of the 5G4 α-synuclein antibody. Acta neuropathologica 128(6), 893-5, doi: 10.1007/s00401-014-1364-1.
Bras J, Guerreiro R, Darwent L, Parkkinen L, Ansorge O, Escott-Price V, Hernandez DG, Nalls MA, Clark LN, Honig LS, Marder K, Van Der Flier WM, Lemstra A, Scheltens P, Rogaeva E, St George-Hyslop P, Londos E, Zetterberg H, Ortega-Cubero S, Pastor P, Ferman TJ, Graff-Radford NR, Ross OA, Barber I, Braae A, Brown K, Morgan K, Maetzler W, Berg D, Troakes C, Al-Sarraj S, Lashley T, Compta Y, Revesz T, Lees A, Cairns N, Halliday GM, Mann D, Pickering-Brown S, Dickson DW, Singleton A, Hardy J (2014), Genetic analysis implicates APOE, SNCA and suggests lysosomal dysfunction in the etiology of dementia with Lewy bodies. Human molecular genetics 23(23), 6139-46, doi: 10.1093/hmg/ddu334.
Heinzel S, Gold M, Deuschle C, Bernhard F, Maetzler W, Berg D, Dodel R (2014), Naturally occurring alpha-synuclein autoantibodies in Parkinson's disease: sources of (error) variance in biomarker assays. PloS one 9(12), e114566, doi: 10.1371/journal.pone.0114566.
Gräber S, Liepelt-Scarfone I, Csoti I, Maetzler W, Sultan F, Berg D (2014), Post-cueing deficits with maintained cueing benefits in patients with Parkinson's disease dementia. Frontiers in neurology 5, 236, doi: 10.3389/fneur.2014.00236.
Hobert MA, Maetzler W, Aminian K, Chiari L (2014), Technical and clinical view on ambulatory assessment in Parkinson's disease. Acta neurologica Scandinavica 130(3), 139-47, doi: 10.1111/ane.12248.
Fritschi SK, Langer F, Kaeser SA, Maia LF, Portelius E, Pinotsi D, Kaminski CF, Winkler DT, Maetzler W, Keyvani K, Spitzer P, Wiltfang J, Kaminski Schierle GS, Zetterberg H, Staufenbiel M, Jucker M (2014), Highly potent soluble amyloid-β seeds in human Alzheimer brain but not cerebrospinal fluid. Brain 137(Pt 11), 2909-2915, doi: 10.1093/brain/awu255.
van der Zee J, Van Langenhove T, Kovacs GG, Dillen L, Deschamps W, Engelborghs S, Matěj R, Vandenbulcke M, Sieben A, Dermaut B, Smets K, Van Damme P, Merlin C, Laureys A, Van Den Broeck M, Mattheijssens M, Peeters K, Benussi L, Binetti G, Ghidoni R, Borroni B, Padovani A, Archetti S, Pastor P, Razquin C, Ortega-Cubero S, Hernández I, Boada M, Ruiz A, de Mendonça A, Miltenberger-Miltényi G, do Couto FS, Sorbi S, Nacmias B, Bagnoli S, Graff C, Chiang H-H, Thonberg H, Perneczky R, Diehl-Schmid J, Alexopoulos P, Frisoni GB, Bonvicini C, Synofzik M, Maetzler W, Müller vom Hagen J, Schöls L, Haack TB, Strom TM, Prokisch H, Dols-Icardo O, Clarimón J, Lleó A, Santana I, Almeida MR, Santiago B, Heneka MT, Jessen F, Ramirez A, Sanchez-Valle R, Llado A, Gelpi E, Sarafov S, Tournev I, Jordanova A, Parobkova E, Fabrizi GM, Testi S, Salmon E, Ströbel T, Santens P, Robberecht W, De Jonghe P, Martin J-J, Cras P, Vandenberghe R, De Deyn PP, Cruts M, Sleegers K, Van Broeckhoven C (2014), Rare mutations in SQSTM1 modify susceptibility to frontotemporal lobar degeneration. Acta neuropathologica 128(3), 397-410, doi: 10.1007/s00401-014-1298-7.
Vijayaraghavan S, Maetzler W, Reimold M, Lithner CU, Liepelt-Scarfone I, Berg D, Darreh-Shori T (2014), High apolipoprotein E in cerebrospinal fluid of patients with Lewy body disorders is associated with dementia. Alzheimer's & dementia 10(5), 530-540.e1, doi: 10.1016/j.jalz.2013.03.010.
Heni M, Schöpfer P, Peter A, Sartorius T, Fritsche A, Synofzik M, Häring H-U, Maetzler W, Hennige AM (2014), Evidence for altered transport of insulin across the blood-brain barrier in insulin-resistant humans. Acta diabetologica 51(4), 679-81, doi: 10.1007/s00592-013-0546-y.
Benzinger P, Rapp K, Maetzler W, König H-H, Jaensch A, Klenk J, Büchele G (2014), Risk for femoral fractures in Parkinson's disease patients with and without severe functional impairment. PloS one 9(5), e97073, doi: 10.1371/journal.pone.0097073.
Heinzel S, Liepelt-Scarfone I, Roeben B, Nasi-Kordhishti I, Suenkel U, Wurster I, Brockmann K, Fritsche A, Niebler R, Metzger FG, Eschweiler GW, Fallgatter AJ, Maetzler W, Berg D (2014), A neurodegenerative vascular burden index and the impact on cognition. Frontiers in aging neuroscience 6, 161, doi: 10.3389/fnagi.2014.00161.
Gaenslen A, Wurster I, Brockmann K, Huber H, Godau J, Faust B, Lerche S, Eschweiler GW, Maetzler W, Berg D (2014), Prodromal features for Parkinson's disease--baseline data from the TREND study. European journal of neurology 21(5), 766-72, doi: 10.1111/ene.12382.
Tolosa E, Litvan I, Höglinger GU, Burn D, Lees A, Andrés MV, Gómez-Carrillo B, León T, Del Ser T, TAUROS Investigators (2014), A phase 2 trial of the GSK-3 inhibitor tideglusib in progressive supranuclear palsy. Movement disorders 29(4), 470-8, doi: 10.1002/mds.25824.
Höglinger GU, Huppertz H-J, Wagenpfeil S, Andrés MV, Belloch V, León T, Del Ser T, TAUROS MRI Investigators (2014), Tideglusib reduces progression of brain atrophy in progressive supranuclear palsy in a randomized trial. Movement disorders 29(4), 479-87, doi: 10.1002/mds.25815.
Lerche S, Hobert M, Brockmann K, Wurster I, Gaenslen A, Hasmann S, Eschweiler GW, Maetzler W, Berg D (2014), Mild parkinsonian signs in the elderly--is there an association with PD? Crossectional findings in 992 individuals. PloS one 9(3), e92878, doi: 10.1371/journal.pone.0092878.
Mielke MM, Maetzler W (2014), A 'bird's eye' view on the current status and potential benefits of blood biomarkers for Parkinson's disease. Biomarkers in medicine 8(2), 225-7, doi: 10.2217/bmm.13.139.
Maetzler W (2014), Comment: why do nondopaminergic features in Parkinson disease matter? Neurology 82(5), 417, doi: 10.1212/WNL.0000000000000095.
Maetzler W, Apel A, Langkamp M, Deuschle C, Dilger SS, Stirnkorb JG, Schulte C, Schleicher E, Gasser T, Berg D (2014), Comparable autoantibody serum levels against amyloid- and inflammation-associated proteins in Parkinson's disease patients and controls. PloS one 9(2), e88604, doi: 10.1371/journal.pone.0088604.
Nalls MA, Pankratz N, Lill CM, Do CB, Hernandez DG, Saad M, DeStefano AL, Kara E, Bras J, Sharma M, Schulte C, Keller MF, Arepalli S, Letson C, Edsall C, Stefansson H, Liu X, Pliner H, Lee JH, Cheng R, (IPDGC) IP's DGC, (PROGENI) P's SG (PSG) P's R: TOGENI, 23andMe, GenePD, (NGRC) NGRC, (HIHG) HI of HG, Investigator AJD, (CHARGE) C for H and AR in GE, (NABEC) NABEC, (UKBEC) UKBEC, Greek Parkinson's Disease Consortium G, Group AGA, Ikram MA, Ioannidis JPA, Hadjigeorgiou GM, Bis JC, Martinez M, Perlmutter JS, Goate A, Marder K, Fiske B, Sutherland M, Xiromerisiou G, Myers RH, Clark LN, Stefansson K, Hardy JA, Heutink P, Chen H, Wood NW, Houlden H, Payami H, Brice A, Scott WK, Gasser T, Bertram L, Eriksson N, Foroud T, Singleton AB (2014), Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease. Nature genetics 46(9), 989-93, doi: 10.1038/ng.3043.
Maetzler W, Domingos J, Srulijes K, Ferreira JJ, Bloem BR (2013), Quantitative wearable sensors for objective assessment of Parkinson's disease. Movement disorders 28(12), 1628-37, doi: 10.1002/mds.25628.
Liepelt-Scarfone I, Fruhmann Berger M, Prakash D, Csoti I, Gräber S, Maetzler W, Berg D (2013), Clinical characteristics with an impact on ADL functions of PD patients with cognitive impairment indicative of dementia. PloS one 8(12), e82902, doi: 10.1371/journal.pone.0082902.
Brockmann K, Schulte C, Hauser A-K, Lichtner P, Huber H, Maetzler W, Berg D, Gasser T (2013), SNCA: major genetic modifier of age at onset of Parkinson's disease. Movement disorders 28(9), 1217-21, doi: 10.1002/mds.25469.
Nalls MA, Duran R, Lopez G, Kurzawa-Akanbi M, McKeith IG, Chinnery PF, Morris CM, Theuns J, Crosiers D, Cras P, Engelborghs S, De Deyn PP, Van Broeckhoven C, Mann DMA, Snowden J, Pickering-Brown S, Halliwell N, Davidson Y, Gibbons L, Harris J, Sheerin U-M, Bras J, Hardy J, Clark L, Marder K, Honig LS, Berg D, Maetzler W, Brockmann K, Gasser T, Novellino F, Quattrone A, Annesi G, De Marco EV, Rogaeva E, Masellis M, Black SE, Bilbao JM, Foroud T, Ghetti B, Nichols WC, Pankratz N, Halliday G, Lesage S, Klebe S, Durr A, Duyckaerts C, Brice A, Giasson BI, Trojanowski JQ, Hurtig HI, Tayebi N, Landazabal C, Knight MA, Keller M, Singleton AB, Wolfsberg TG, Sidransky E (2013), A multicenter study of glucocerebrosidase mutations in dementia with Lewy bodies. JAMA neurology 70(6), 727-35, doi: 10.1001/jamaneurol.2013.1925.
Mielke MM, Maetzler W, Haughey NJ, Bandaru VVR, Savica R, Deuschle C, Gasser T, Hauser A-K, Gräber-Sultan S, Schleicher E, Berg D, Liepelt-Scarfone I (2013), Plasma ceramide and glucosylceramide metabolism is altered in sporadic Parkinson's disease and associated with cognitive impairment: a pilot study. PloS one 8(9), e73094, doi: 10.1371/journal.pone.0073094.
Koehler NKU, Stransky E, Shing M, Gaertner S, Meyer M, Schreitmüller B, Leyhe T, Laske C, Maetzler W, Kahle P, Celej MS, Jovin TM, Fallgatter AJ, Batra A, Buchkremer G, Schott K, Richartz-Salzburger E (2013), Altered serum IgG levels to α-synuclein in dementia with Lewy bodies and Alzheimer's disease. PloS one 8(5), e64649, doi: 10.1371/journal.pone.0064649.
Liscic RM, Srulijes K, Gröger A, Maetzler W, Berg D (2013), Differentiation of progressive supranuclear palsy: clinical, imaging and laboratory tools. Acta neurologica Scandinavica 127(5), 362-70, doi: 10.1111/ane.12067.
Maetzler W, Nieuwhof F, Hasmann SE, Bloem BR (2013), Emerging therapies for gait disability and balance impairment: promises and pitfalls. Movement disorders 28(11), 1576-86, doi: 10.1002/mds.25682.
Berg D, Lang AE, Postuma RB, Maetzler W, Deuschl G, Gasser T, Siderowf A, Schapira AH, Oertel W, Obeso JA, Olanow CW, Poewe W, Stern M (2013), Changing the research criteria for the diagnosis of Parkinson's disease: obstacles and opportunities. The lancet neurology 12(5), 514-24, doi: 10.1016/S1474-4422(13)70047-4.
Heinzel S, Metzger FG, Ehlis A-C, Korell R, Alboji A, Haeussinger FB, Hagen K, Maetzler W, Eschweiler GW, Berg D, Fallgatter AJ, TREND Study Consortium (2013), Aging-related cortical reorganization of verbal fluency processing: a functional near-infrared spectroscopy study. Neurobiology of aging 34(2), 439-50, doi: 10.1016/j.neurobiolaging.2012.05.021.
Srulijes K, Hauser A-K, Guella I, Asselta R, Brockmann K, Schulte C, Soldà G, Cilia R, Maetzler W, Schols L, Wenning GK, Poewe W, Barone P, Wüllner U, Oertel W, Berg D, Goldwurm S, Gasser T (2013), No association of GBA mutations and multiple system atrophy. European journal of neurology 20(4), e61-2, doi: 10.1111/ene.12086.
Leyhe T, Darreh-Shori T, Laske C, Mielke MM, Maetzler W (2013), Biomarkers in Alzheimer's disease and lewy body disorders with dementia. International journal of Alzheimer's disease 2013, 473181, doi: 10.1155/2013/473181.
Laske C, Schmohl M, Leyhe T, Stransky E, Maetzler W, Berg D, Fallgatter AJ, Joos T, Dietzsch J (2013), Immune profiling in blood identifies sTNF-R1 performing comparably well as biomarker panels for classification of Alzheimer's disease patients. Journal of Alzheimer's disease 34(2), 367-75, doi: 10.3233/JAD-121558.
Berg D, Godau J, Seppi K, Behnke S, Liepelt-Scarfone I, Lerche S, Stockner H, Gaenslen A, Mahlknecht P, Huber H, Srulijes K, Klenk J, Fassbender K, Maetzler W, Poewe W, PRIPS study group (2013), The PRIPS study: screening battery for subjects at risk for Parkinson's disease. European journal of neurology 20(1), 102-8, doi: 10.1111/j.1468-1331.2012.03798.x.
van der Zee J, Gijselinck I, Dillen L, Van Langenhove T, Theuns J, Engelborghs S, Philtjens S, Vandenbulcke M, Sleegers K, Sieben A, Bäumer V, Maes G, Corsmit E, Borroni B, Padovani A, Archetti S, Perneczky R, Diehl-Schmid J, de Mendonça A, Miltenberger-Miltenyi G, Pereira S, Pimentel J, Nacmias B, Bagnoli S, Sorbi S, Graff C, Chiang H-H, Westerlund M, Sanchez-Valle R, Llado A, Gelpi E, Santana I, Rosário Almeida M, Santiago B, Frisoni G, Zanetti O, Bonvicini C, Synofzik M, Maetzler W, Müller Vom Hagen J, Schöls L, Heneka MT, Jessen F, Matej R, Parobkova E, Kovacs GG, Ströbel T, Sarafov S, Tournev I, Jordanova A, Danek A, Arzberger T, Maria Fabrizi G, Testi S, Salmon E, Santens P, Martin J-J, Cras P, Vandenberghe R, De Deyn PP, Cruts M, Van Broeckhoven C, Ramirez A, Kurzwelly D, Sachtleben C, Mairer W, Firmo C, Antonell A, Molinuevo J, Kinhult Ståhlbom A, Thonberg H, Nennesmo I, Börjesson-Hanson A, Bessi V, Piaceri I, Helena Ribeiro M, Oliveira C, Massano J, Garret C, Pires P, Danel A, Ferrari S, Cavallaro T, Consortium EE-OD (2013), A pan-European study of the C9orf72 repeat associated with FTLD: geographic prevalence, genomic instability, and intermediate repeats. Human mutation 34(2), 363-73, doi: 10.1002/humu.22244.
Liepelt-Scarfone I, Gauss K, Maetzler W, Müller K, Bormann C, Fruhmann Berger M, Timmers M, Streffer J, Berg D (2013), Evaluation of progression markers in the premotor phase of Parkinson's disease: the progression markers in the premotor phase study. Neuroepidemiology 41(3-4), 174-82, doi: 10.1159/000353560.
Schwickert L, Becker C, Lindemann U, Maréchal C, Bourke A, Chiari L, Helbostad JL, Zijlstra W, Aminian K, Todd C, Bandinelli S, Klenk J, FARSEEING Consortium and the FARSEEING Meta Database Consensus Group (2013), Fall detection with body-worn sensors. Zeitschrift für Gerontologie und Geriatrie 46(8), 706-719, doi: 10.1007/s00391-013-0559-8.
Klenk J, Chiari L, Helbostad JL, Zijlstra W, Aminian K, Todd C, Bandinelli S, Kerse N, Schwickert L, Mellone S, Bagalá F, Delbaere K, Hauer K, Redmond SJ, Robinovitch S, Aziz O, Schwenk M, Zecevic A, Zieschang T, Becker C, FARSEEING Consortium and the FARSEEING Meta-Database Consensus Group (2013), Development of a standard fall data format for signals from body-worn sensors. Zeitschrift für Gerontologie und Geriatrie 46(8), 720-726, doi: 10.1007/s00391-013-0554-0.
Synofzik M, Maetzler W, Grehl T, Prudlo J, Müller Vom Hagen J, Haack T, Rebassoo P, Munz M, Schöls L, Biskup S (2012), Screening in ALS and FTD patients reveals 3 novel UBQLN2 mutations outside the PXX domain and a pure FTD phenotype. Neurobiology of aging 33(12), 2949.e13-7, doi: 10.1016/j.neurobiolaging.2012.07.002.
Maetzler W, Klenk J, Becker C, Zscheile J, Gabor K-S, Lindemann U (2012), Longitudinal changes of nerve conduction velocity, distal motor latency, compound motor action potential duration, and skin temperature during prolonged exposure to cold in a climate chamber. The International journal of neuroscience 122(9), 528-31, doi: 10.3109/00207454.2012.685531.
Deleidi M, Maetzler W (2012), Protein clearance mechanisms of alpha-synuclein and amyloid-Beta in lewy body disorders. International journal of Alzheimer's disease 2012, 391438, doi: 10.1155/2012/391438.
Schmid SP, Schleicher ED, Cegan A, Deuschle C, Baur S, Hauser A-K, Synofzik M, Srulijes K, Brockmann K, Berg D, Maetzler W (2012), Cerebrospinal fluid fatty acids in glucocerebrosidase-associated Parkinson's disease. Movement disorders 27(2), 288-92, doi: 10.1002/mds.23984.
Gerlach M, Maetzler W, Broich K, Hampel H, Rems L, Reum T, Riederer P, Stöffler A, Streffer J, Berg D (2012), Biomarker candidates of neurodegeneration in Parkinson's disease for the evaluation of disease-modifying therapeutics. Journal of neural transmission 119(1), 39-52, doi: 10.1007/s00702-011-0682-x.
Maetzler W, Tian Y, Baur SM, Gauger T, Odoj B, Schmid B, Schulte C, Deuschle C, Heck S, Apel A, Melms A, Gasser T, Berg D (2012), Serum and cerebrospinal fluid levels of transthyretin in Lewy body disorders with and without dementia. PloS one 7(10), e48042, doi: 10.1371/journal.pone.0048042.
Jamour M, Becker C, Synofzik M, Maetzler W (2012), [Gait changes as an early indicator of dementia]. Zeitschrift für Gerontologie und Geriatrie 45(1), 40-4, doi: 10.1007/s00391-011-0260-8.
Sathe K, Maetzler W, Lang JD, Mounsey RB, Fleckenstein C, Martin HL, Schulte C, Mustafa S, Synofzik M, Vukovic Z, Itohara S, Berg D, Teismann P (2012), S100B is increased in Parkinson's disease and ablation protects against MPTP-induced toxicity through the RAGE and TNF-α pathway. Brain 135(Pt 11), 3336-47, doi: 10.1093/brain/aws250.
Maetzler W, Langkamp M, Lerche S, Godau J, Brockmann K, Gaenslen A, Huber H, Wurster I, Niebler R, Eschweiler GW, Berg D (2012), Lowered serum amyloid-β1-42 autoantibodies in individuals with lifetime depression. Journal of Alzheimer's disease 32(1), 95-100, doi: 10.3233/JAD-2012-120625.
Srulijes K, Reimold M, Liscic RM, Bauer S, Dietzel E, Liepelt-Scarfone I, Berg D, Maetzler W (2012), Fluorodeoxyglucose positron emission tomography in Richardson’s syndrome and progressive supranuclear palsy-parkinsonism. Movement disorders 27(1), 151-5.
Maetzler W, Mancini M, Liepelt-Scarfone I, Müller K, Becker C, van Lummel RC, Ainsworth E, Hobert M, Streffer J, Berg D, Chiari L (2012), Impaired trunk stability in individuals at high risk for Parkinson's disease. PloS one 7(3), e32240, doi: 10.1371/journal.pone.0032240.
Liepelt-Scarfone I, Jamour M, Maetzler W (2012), Co-occurrence of parkinsonism and dementia in clinical practice: relevant differential diagnoses. Zeitschrift für Gerontologie und Geriatrie 45(1), 23-33, doi: 10.1007/s00391-011-0261-7.
Maetzler W, Hausdorff JM (2012), Reply: Presyndromic phase: proposal for a new term for an emerging concept. Movement disorders 27(12), 1583-4; author reply 1584-5, doi: 10.1002/mds.25210.
Becker C, Schwickert L, Mellone S, Bagalà F, Chiari L, Helbostad JL, Zijlstra W, Aminian K, Bourke A, Todd C, Bandinelli S, Kerse N, Klenk J, FARSEEING Consortium, FARSEEING Meta Database Consensus Group (2012), Proposal for a multiphase fall model based on real-world fall recordings with body-fixed sensors. Zeitschrift für Gerontologie und Geriatrie 45(8), 707-15, doi: 10.1007/s00391-012-0403-6.
Adame MR, Al-Jawad A, Romanovas M, Hobert MA, Maetzler W, Möller K, Manoli Y (2012), TUG Test Instrumentation for Parkinson’s disease patients using Inertial Sensors and Dynamic Time Warping. Biomedical Engineering 57(Suppl 1), 1071-1074, doi: 10.1515/bmt-2012-4426.
Maetzler W, Hausdorff JM (2012), Motor signs in the prodromal phase of Parkinson's disease. Movement disorders 27(5), 627-633, doi: 10.1002/mds.24973.
Maetzler W, Reimold M, Schittenhelm J, Vorgerd M, Bornemann A, Kötter I, Pfannenberg C, Reischl G, Schöls L (2011), Increased [11C]PIB-PET levels in inclusion body myositis are indicative of amyloid beta deposition. Journal of neurology, neurosurgery, and psychiatry 82(9), 1060-2, doi: 10.1136/jnnp.2009.197640.
Liepelt I, Behnke S, Schweitzer K, Wolf B, Godau J, Wollenweber F, Dillmann U, Gaenslen A, Di Santo A, Maetzler W, Berg D (2011), Pre-motor signs of PD are related to SN hyperechogenicity assessed by TCS in an elderly population. Neurobiology of aging 32(9), 1599-606, doi: 10.1016/j.neurobiolaging.2009.10.004.
Srulijes K, Mallien G, Bauer S, Dietzel E, Gröger A, Ebersbach G, Berg D, Maetzler W (2011), In vivo comparison of Richardson's syndrome and progressive supranuclear palsy-parkinsonism. Journal of neural transmission 118(8), 1191-7, doi: 10.1007/s00702-010-0563-8.
Brockmann K, Gröger A, Di Santo A, Liepelt I, Schulte C, Klose U, Maetzler W, Hauser A-K, Hilker R, Gomez-Mancilla B, Berg D, Gasser T (2011), Clinical and brain imaging characteristics in leucine-rich repeat kinase 2-associated PD and asymptomatic mutation carriers. Movement disorders 26(13), 2335-42, doi: 10.1002/mds.23991.
Godau J, Knauel K, Weber K, Brockmann K, Maetzler W, Binder G, Berg D (2011), Serum insulinlike growth factor 1 as possible marker for risk and early diagnosis of Parkinson disease. Archives of neurology 68(7), 925-31, doi: 10.1001/archneurol.2011.129.
Berg D, Seppi K, Behnke S, Liepelt I, Schweitzer K, Stockner H, Wollenweber F, Gaenslen A, Mahlknecht P, Spiegel J, Godau J, Huber H, Srulijes K, Kiechl S, Bentele M, Gasperi A, Schubert T, Hiry T, Probst M, Schneider V, Klenk J, Sawires M, Willeit J, Maetzler W, Fassbender K, Gasser T, Poewe W (2011), Enlarged substantia nigra hyperechogenicity and risk for Parkinson disease: a 37-month 3-center study of 1847 older persons. Archives of neurology 68(7), 932-7, doi: 10.1001/archneurol.2011.141.
Laske C, Fallgatter AJ, Stransky E, Hagen K, Berg D, Maetzler W (2011), Decreased α-synuclein serum levels in patients with Lewy body dementia compared to Alzheimer's disease patients and control subjects. Dementia and geriatric cognitive disorders 31(6), 413-6, doi: 10.1159/000329763.
Klenk J, Becker C, Lieken F, Nicolai S, Maetzler W, Alt W, Zijlstra W, Hausdorff JM, van Lummel RC, Chiari L, Lindemann U (2011), Comparison of acceleration signals of simulated and real-world backward falls. Medical engineering & physics 33(3), 368-73, doi: 10.1016/j.medengphy.2010.11.003.
Maetzler W, Stapf AK, Schulte C, Hauser A-K, Lerche S, Wurster I, Schleicher E, Melms A, Berg D (2011), Serum and cerebrospinal fluid uric acid levels in lewy body disorders: associations with disease occurrence and amyloid-β pathway. Journal of Alzheimer's disease 27(1), 119-26, doi: 10.3233/JAD-2011-110587.
Maetzler W, Berg D, Synofzik M, Brockmann K, Godau J, Melms A, Gasser T, Hörnig S, Langkamp M (2011), Autoantibodies against amyloid and glial-derived antigens are increased in serum and cerebrospinal fluid of Lewy body-associated dementias. Journal of Alzheimer's disease 26(1), 171-9, doi: 10.3233/JAD-2011-110221.
Maetzler W, Schmid SP, Wurster I, Liepelt I, Gaenslen A, Gasser T, Berg D (2011), Reduced but not oxidized cerebrospinal fluid glutathione levels are lowered in Lewy body diseases. Movement disorders 26(1), 176-81, doi: 10.1002/mds.23358.
Höglinger GU, Melhem NM, Dickson DW, Sleiman PMA, Wang L-S, Klei L, Rademakers R, de Silva R, Litvan I, Riley DE, van Swieten JC, Heutink P, Wszolek ZK, Uitti RJ, Vandrovcova J, Hurtig HI, Gross RG, Maetzler W, Goldwurm S, Tolosa E, Borroni B, Pastor P, PSP Genetics Study Group RL, Cantwell LB, Han MR, Dillman A, van der Brug MP, Gibbs JR, Cookson MR, Hernandez DG, Singleton AB, Farrer MJ, Yu C-E, Golbe LI, Revesz T, Hardy J, Lees AJ, Devlin B, Hakonarson H, Müller U, Schellenberg GD, De Deyn PP, de Yebenes JG, Kaat LD, Duara R, Durr A, Engelborghs S, Fabbrini G, Finch NA, Flook R, Frosch MP, Gaig C, Galasko DR, Gasser T, Gearing M, Geller ET, Ghetti B, Graff-Radford NR, Grossman M, Hall DA, Hazrati L-N, Höllerhage M, Jankovic J, Juncos JL, Karydas A, Kretzschmar HA, Leber I, Lee VM, Lieberman AP, Lyons KE, Mariani C, Masliah E, Massey LA, McLean CA, Meucci N, Miller BL, Mollenhauer B, Möller JC, Morris HR, Morris C, O'Sullivan SS, Oertel WH, Ottaviani D, Padovani A, Pahwa R, Pezzoli G, Pickering-Brown S, Poewe W, Rabano A, Rajput A, Reich SG, Respondek G, Roeber S, Rohrer JD, Ross OA, Rossor MN, Sacilotto G, Seeley WW, Seppi K, Silveira-Moriyama L, Spina S, Srulijes K, St. George-Hyslop P, Stamelou M, Standaert DG, Tesei S, Tourtellotte WW, Trenkwalder C, Troakes C, Trojanowski JQ, Troncoso JC, Van Deerlin VM, Vonsattel JPG, Wenning GK, White CL, Winter P, Zarow C, Zecchinelli AL, Cantwell LB, Han MR, Dillman A, van der Brug MP, Gibbs JR, Cookson MR, Hernandez DG, Singleton AB, Farrer MJ, Yu C-E, Golbe LI, Revesz T, Hardy J, Lees AJ, Devlin B, Hakonarson H, Müller U, Schellenberg GD (2011), Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy. Nature genetics 43(7), 699-705, doi: 10.1038/ng.859.
Liepelt-Scarfone I, Graeber S, Feseker A, Baysal G, Godau J, Gaenslen A, Maetzler W, Berg D (2011), Influence of different cut-off values on the diagnosis of mild cognitive impairment in Parkinson's disease. Parkinson's disease 2011, 540843, doi: 10.4061/2011/540843.
Hobert MA, Niebler R, Meyer SI, Brockmann K, Becker C, Huber H, Gaenslen A, Godau J, Eschweiler GW, Berg D, Maetzler W (2011), Poor trail making test performance is directly associated with altered dual task prioritization in the elderly--baseline results from the TREND study. PloS one 6(11), e27831, doi: 10.1371/journal.pone.0027831.
Synofzik M, Fernández-Santiago R, Maetzler W, Schöls L, Andersen PM (2010), The human G93A SOD1 phenotype closely resembles sporadic amyotrophic lateral sclerosis. Journal of neurology, neurosurgery, and psychiatry 81(7), 764-7, doi: 10.1136/jnnp.2009.181719.
Maetzler W, Stoycheva V, Schmid B, Schulte C, Hauser A-K, Brockmann K, Melms A, Gasser T, Berg D (2010), Neprilysin activity in cerebrospinal fluid is associated with dementia and amyloid-β42 levels in Lewy body disease. Journal of Alzheimer's disease 22(3), 933-8, doi: 10.3233/JAD-2010-101197.
Maetzler W, Schmid B, Synofzik M, Schulte C, Riester K, Huber H, Brockmann K, Gasser T, Berg D, Melms A (2010), The CST3 BB genotype and low cystatin C cerebrospinal fluid levels are associated with dementia in Lewy body disease. Journal of Alzheimer's disease 19(3), 937-42, doi: 10.3233/JAD-2010-1289.
Maetzler W, Berg D, Funke C, Sandmann F, Stünitz H, Maetzler C, Nitsch C (2010), Progressive secondary neurodegeneration and microcalcification co-occur in osteopontin-deficient mice. The American journal of pathology 177(2), 829-39, doi: 10.2353/ajpath.2010.090798.
Berg D, Seppi K, Liepelt I, Schweitzer K, Wollenweber F, Wolf B, Dillmann U, Stockner H, Godau J, Kiechl S, Gaenslen A, Willeit J, Di Santo A, Maetzler W, Gasser T, Poewe W, Behnke S (2010), Enlarged hyperechogenic substantia nigra is related to motor performance and olfaction in the elderly. Movement disorders 25(10), 1464-9, doi: 10.1002/mds.23114.
Lindemann U, Nicolai S, Beische D, Becker C, Srulijes K, Dietzel E, Bauer S, Berg D, Maetzler W (2010), Clinical and dual-tasking aspects in frequent and infrequent fallers with progressive supranuclear palsy. Movement disorders 25(8), 1040-6, doi: 10.1002/mds.23023.
Nicolai S, Mirelman A, Herman T, Zijlstra A, Mancini M, Becker C, Lindemann U, Berg D, Maetzler W (2010), Improvement of balance after audio-biofeedback. A 6-week intervention study in patients with progressive supranuclear palsy. Zeitschrift für Gerontologie und Geriatrie 43(4), 224-8, doi: 10.1007/s00391-010-0125-6.
Laske C, Stransky E, Hoffmann N, Maetzler W, Straten G, Eschweiler GW, Leyhe T (2010), Macrophage Colony-Stimulating Factor (M-CSF) in Plasma and CSF of Patients with Mild Cognitive Impairment and Alzheimers Disease. Current Alzheimer research 7(5), 409-414, doi: 10.2174/156720510791383813.
Maetzler W, Keller S, Michelis J, Koehler N, Stransky E, Becker C, Schulte C, Melms A, Gasser T, Berg D (2009), No differences of butyrylcholinesterase protein activity and allele frequency in Lewy body diseases. Neurobiology of disease 35(2), 296-301, doi: 10.1016/j.nbd.2009.05.014.
Maetzler W, Michelis J, Tomiuk J, Melms A, Becker C, Gasser T, Schulte C, Berg D (2009), A single-nucleotide polymorphism of the osteopontin gene may contribute to a susceptibility to Lewy body disease. Journal of neural transmission 116(5), 599-605, doi: 10.1007/s00702-009-0209-x.
Liepelt I, Reimold M, Maetzler W, Godau J, Reischl G, Gaenslen A, Herbst H, Berg D (2009), Cortical hypometabolism assessed by a metabolic ratio in Parkinson's disease primarily reflects cognitive deterioration-[18F]FDG-PET. Movement disorders 24(10), 1504-11, doi: 10.1002/mds.22662.
Maetzler W, Liepelt I, Berg D (2009), Progression of Parkinson's disease in the clinical phase: potential markers. The lancet neurology 8(12), 1158-71, doi: 10.1016/S1474-4422(09)70291-1.
Maetzler W, Liepelt I, Reimold M, Reischl G, Solbach C, Becker C, Schulte C, Leyhe T, Keller S, Melms A, Gasser T, Berg D (2009), Cortical PIB binding in Lewy body disease is associated with Alzheimer-like characteristics. Neurobiology of disease 34(1), 107-12, doi: 10.1016/j.nbd.2008.12.008.
Maetzler W, Stünitz H, Bendfeldt K, Vollenweider F, Schwaller B, Nitsch C (2009), Microcalcification after excitotoxicity is enhanced in transgenic mice expressing parvalbumin in all neurones, may commence in neuronal mitochondria and undergoes structural modifications over time. Neuropathology and applied neurobiology 35(2), 165-77, doi: 10.1111/j.1365-2990.2008.00970.x.
Straten G, Eschweiler GW, Maetzler W, Laske C, Leyhe T (2009), Glial cell-line derived neurotrophic factor (GDNF) concentrations in cerebrospinal fluid and serum of patients with early Alzheimer's disease and normal controls. Journal of Alzheimer's disease 18(2), 331-7, doi: 10.3233/JAD-2009-1146.
Maetzler W, Reimold M, Liepelt I, Solbach C, Leyhe T, Schweitzer K, Eschweiler GW, Mittelbronn M, Gaenslen A, Uebele M, Reischl G, Gasser T, Machulla H-J, Bares R, Berg D (2008), [11C]PIB binding in Parkinson's disease dementia. NeuroImage 39(3), 1027-33, doi: 10.1016/j.neuroimage.2007.09.072.
Liepelt I, Maetzler W, Blaicher H-P, Gasser T, Berg D (2008), [Treatment for dementia in parkinsonian syndromes. Efficacy of cholinesterase inhibitors]. Der Nervenarzt 79(1), 36-9, 42-6, doi: 10.1007/s00115-007-2312-2.
Maetzler W, Berg D, Schalamberidze N, Melms A, Schott K, Mueller JC, Liaw L, Gasser T, Nitsch C (2007), Osteopontin is elevated in Parkinson's disease and its absence leads to reduced neurodegeneration in the MPTP model. Neurobiology of disease 25(3), 473-82, doi: 10.1016/j.nbd.2006.10.020.
Rossi C, Boss A, Lindig TM, Martirosian P, Steidle G, Maetzler W, Claussen CD, Klose U, Schick F (2007), Diffusion tensor imaging of the spinal cord at 1.5 and 3.0 Tesla. RoFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin 179(3), 219-24, doi: 10.1055/s-2007-962832.
Laske C, Stransky E, Leyhe T, Eschweiler GW, Maetzler W, Wittorf A, Soekadar S, Richartz E, Koehler N, Bartels M, Buchkremer G, Schott K (2007), BDNF serum and CSF concentrations in Alzheimer's disease, normal pressure hydrocephalus and healthy controls. Journal of psychiatric research 41(5), 387-94, doi: 10.1016/j.jpsychires.2006.01.014.
Liepelt I, Maetzler W, Blaicher H-P, Gasser T, Berg D (2007), Treatment of dementia in parkinsonian syndromes with cholinesterase inhibitors. Dementia and geriatric cognitive disorders 23(6), 351-67, doi: 10.1159/000101337.
Mätzler W, Nägele T, Gasser T, Krüger R (2007), Acute parkinsonism with corresponding lesions in the basal ganglia after heroin abuse. Neurology 68(6), 414, doi: 10.1212/01.wnl.0000250230.86581.ea.
Synofzik M, Maetzler W (2007), How should we treat dementia patients? The ethically problematic function of antidementia drugs. Ethik in der Medizin 19(4), 270-80, doi: 10.1007/s00481-007-0532-4.
Vollenweider F, Bendfeldt K, Maetzler W, Otten U, Nitsch C (2006), GABA(B) receptor expression and cellular localization in gerbil hippocampus after transient global ischemia. Neuroscience letters 395(2), 118-23, doi: 10.1016/j.neulet.2005.10.079.
Maetzler W, Nitsch C, Bendfeldt K, Racay P, Vollenweider F, Schwaller B (2004), Ectopic parvalbumin expression in mouse forebrain neurons increases excitotoxic injury provoked by ibotenic acid injection into the striatum. Experimental neurology 186(1), 78-88, doi: 10.1016/j.expneurol.2003.10.014.
Haller R, Kemmler G, Kocsis E, Maetzler W, Prunlechner R, Hinterhuber H (2001), Schizophrenie und Gewalttätigkeit. Der Nervenarzt 72(11), 859-866, doi: 10.1007/s001150170020.
Maetzler W, Berg D (2010), Biomarkers of Alzheimer’s and Parkinson’s Disease., in: V.S. Vaidya, Bonventre, J.V. (Eds.), Biomarkers Of Toxicity. John Wiley & Sons, Inc., pp. 89-117, doi: doi.org/10.1002/9780470918562.ch6.
Srulijes K, Maetzler W (2015), Progressive Supranuclear Palsy and Dementia., in: C.R. Martin, Preedy, V.R. (Eds.), Diet And Nutrition In Dementia And Cognitive Decline. Elsevier, pp. 147-157, doi: doi.org/10.1016/B978-0-12-407824-6.00014-8.
Maetzler W, Grond M, Jacobs AH (2016), Neurogeriatrie., in: W. Hacke (Ed.), Neurologie. Springer Berlin Heidelberg, pp. 959-970.
Maetzler W, Grond M, Dodel R (2017), Neurogeriatrie., in: H.C. Diener, Gerloff, C., Dieterich, M. (Eds.), Therapie Und Verlauf Neurologischer Erkrankungen. Kohlhammer, pp. 1607-1622.
Maetzler W, Dodel R, Jacobs AH (2020), Neurogeriatrie: ICF-basierte Diagnose und Behandlung. Springer, doi: 10.1007/978-3-662-57358-7.
Maetzler W, Deuschl G (2020), Gang- und Gleichgewichtsstörungen., in: G. Deuschl, Oertel, W.H., Poewe, W. (Eds.), Parkinson-Syndrome Und Andere Bewegungsstörungen. Thieme, pp. 494-511, doi: doi:10.1055/b-006-163222.
Weiss M, Maetzler W (2021), Der stürzende Patient., in: C. Eggers, Buhmann, C. (Eds.), Parkinson. Fallbeispiele Aus Der Klinik. Kohlhammer, pp. 103-113.
Moscovic M, LaFaver K, Maetzler W (2022), Functional Movement Disorder in Older Adults., in: K. LaFaver, Maurer, C.W., Nicholson, T.R., Perez, D.L. (Eds.), Functional Movement Disorder: An Interdisciplinary Case-Based Approach. Springer Nature Switzerland, doi: 10.1007/978-3-030-86495-8.
Pilotto A, Maetzler W (2022), Gerontechnology - A Clinical Perspective. Springer.
Bhidayasiri R, Maetzler W (2022), Handbook of digital technologies in movement disorders. Elsevier.
Maetzler W (2022), Neurologisch-geriatrische Störungen: Epidemiologie, Pathophysiologie, Diagnose und Management., in: J. Bauer, Wirth, R., Denkinger, M., Becker, C. (Eds.), Geriatrie. Kohlhammer.